The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 227: Cyclin-dependent kinase 9
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 28 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
19 |
O17432 (/IPI)
O17432 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
(9 more) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
16 |
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
P50750 (/ISS)
(6 more) |
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
|
16 |
O17432 (/IDA)
O17432 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(6 more) |
RNA polymerase II CTD heptapeptide repeat kinase activity GO:0008353
Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats.
|
16 |
O17432 (/IDA)
O17432 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(6 more) |
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
14 |
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
P50750 (/IPI)
(4 more) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Showing 1 to 10 of 28 entries
There are 49 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of histone phosphorylation GO:0033129
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
|
17 |
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
(7 more) |
Positive regulation of histone H2B ubiquitination GO:2001168
Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination.
|
17 |
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
(7 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
16 |
O17432 (/IMP)
O17432 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
P50750 (/IMP)
(6 more) |
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Regulation of histone modification GO:0031056
Any process that modulates the frequency, rate or extent of the covalent alteration of a histone.
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Showing 1 to 10 of 49 entries
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
28 |
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
(18 more) |
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
28 |
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
A0A024R880 (/IDA)
(18 more) |
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
17 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(7 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
14 |
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
P50750 (/TAS)
(4 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
14 |
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
P50750 (/HDA)
(4 more) |
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
14 |
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
P50750 (/IDA)
(4 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | O17432 (/IDA) O17432 (/IDA) Q641Z4 (/IDA) Q641Z4 (/IDA) Q641Z4 (/IDA) Q99J95 (/IDA) Q99J95 (/IDA) Q99J95 (/IDA) |
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
8 | Q5EAB2 (/ISS) Q5EAB2 (/ISS) Q641Z4 (/ISS) Q641Z4 (/ISS) Q641Z4 (/ISS) Q99J95 (/ISS) Q99J95 (/ISS) Q99J95 (/ISS) |
Showing 1 to 10 of 22 entries