The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Calcium/calmodulin-dependent protein kinase type I...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 48 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
95 O62305 (/IPI) P08413 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI) P11275 (/IPI)
(85 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
73 P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA) P11798 (/IDA)
(63 more)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
66 E7F2G0 (/IDA) G5EDZ5 (/IDA) O62305 (/IDA) P08413 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(56 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
51 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(41 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
44 O62305 (/IPI) Q13554 (/IPI) Q13554 (/IPI) Q13554 (/IPI) Q13555 (/IPI) Q13555 (/IPI) Q13555 (/IPI) Q13557 (/IPI) Q13557 (/IPI) Q13557 (/IPI)
(34 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
43 Q13554 (/IPI) Q13554 (/IPI) Q13554 (/IPI) Q13555 (/IPI) Q13555 (/IPI) Q13555 (/IPI) Q13557 (/IPI) Q13557 (/IPI) Q13557 (/IPI) Q13557 (/IPI)
(33 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
41 P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP)
(31 more)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
41 P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO)
(31 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
41 P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO)
(31 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
41 P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO)
(31 more)
Showing 1 to 10 of 48 entries

There are 195 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
67 O62305 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(57 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
55 E7F2G0 (/IDA) G5EDZ5 (/IDA) O62305 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(45 more)
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
50 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(40 more)
Regulation of neuron migration GO:2001222
Any process that modulates the frequency, rate or extent of neuron migration.
47 P08413 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(37 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
46 P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(36 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
45 A0A2R8RRG1 (/IMP) E7F2G0 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP)
(35 more)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
45 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(35 more)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
43 Q13554 (/TAS) Q13554 (/TAS) Q13554 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS)
(33 more)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
43 Q13554 (/TAS) Q13554 (/TAS) Q13554 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS)
(33 more)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
41 P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP) P11798 (/IMP)
(31 more)
Showing 1 to 10 of 195 entries

There are 60 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
68 P08413 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS) P11275 (/TAS)
(58 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
54 P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS) P11730 (/TAS)
(44 more)
Calcium- and calmodulin-dependent protein kinase complex GO:0005954
An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
47 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(37 more)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
45 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(35 more)
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
43 Q13554 (/TAS) Q13554 (/TAS) Q13554 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13555 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS) Q13557 (/TAS)
(33 more)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
37 P08413 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(27 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
32 P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA) P11275 (/IDA)
(22 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
32 P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS) P11275 (/ISS)
(22 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
31 P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO)
(21 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
31 P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO) P11798 (/ISO)
(21 more)
Showing 1 to 10 of 60 entries
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