The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"ligand-binding face of the semaphorins, domain 2
".
FunFam 5: Integrin beta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 43 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
7 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
6 | A0A286Y9W0 (/IPI) B3DHB6 (/IPI) F1QG85 (/IPI) P49134 (/IPI) Q3YAA0 (/IPI) Q3YAA1 (/IPI) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P05556 (/IPI) P05556 (/IPI) P07228 (/IPI) P09055 (/IPI) P49134 (/IPI) |
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
3 | A0A286Y9W0 (/IGI) F1QG85 (/IGI) Q3YAA1 (/IGI) |
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
3 | P05556 (/IPI) P05556 (/IPI) P49134 (/IPI) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
3 | P05556 (/IDA) P05556 (/IDA) P49134 (/IDA) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | P05556 (/IPI) P05556 (/IPI) P49134 (/IPI) |
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
2 | P05556 (/IPI) P05556 (/IPI) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
2 | P09055 (/IPI) P49134 (/IPI) |
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
|
2 | P05556 (/TAS) P05556 (/TAS) |
Showing 1 to 10 of 43 entries
There are 131 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
11 |
A5Z1X6 (/ISS)
B0FYY4 (/ISS)
P05556 (/ISS)
P05556 (/ISS)
P07228 (/ISS)
P09055 (/ISS)
P49134 (/ISS)
P53712 (/ISS)
P53713 (/ISS)
Q5RCA9 (/ISS)
(1 more) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
9 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P05556 (/ISS) P05556 (/ISS) P09055 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
9 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P05556 (/ISS) P05556 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
|
9 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P05556 (/ISS) P05556 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Regulation of collagen catabolic process GO:0010710
Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
|
8 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
8 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
3 | P05556 (/IMP) P05556 (/IMP) P09055 (/IMP) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P05556 (/IMP) P05556 (/IMP) P49134 (/IMP) |
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
3 | B3DHB6 (/IMP) P09055 (/IMP) Q3YAA0 (/IMP) |
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
|
3 | A0A286Y9W0 (/IGI) F1QG85 (/IGI) Q3YAA1 (/IGI) |
Showing 1 to 10 of 131 entries
There are 82 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
|
12 |
A5Z1X6 (/ISS)
B0FYY4 (/ISS)
P07228 (/ISS)
P09055 (/ISS)
P12606 (/ISS)
P12606 (/ISS)
P12607 (/ISS)
P49134 (/ISS)
P53712 (/ISS)
P53713 (/ISS)
(2 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
8 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P07228 (/ISS) P09055 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
7 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P07228 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
6 | A5Z1X6 (/ISS) B0FYY4 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P05556 (/TAS) P05556 (/TAS) P07228 (/TAS) P09055 (/TAS) P49134 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
5 | F1N8N7 (/IDA) P05556 (/IDA) P05556 (/IDA) P07228 (/IDA) P49134 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | P05556 (/IDA) P05556 (/IDA) P09055 (/IDA) P49134 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P05556 (/IDA) P05556 (/IDA) P09055 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
3 | P05556 (/IDA) P05556 (/IDA) P09055 (/IDA) |
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
|
3 | P05556 (/IDA) P05556 (/IDA) P49134 (/IDA) |
Showing 1 to 10 of 82 entries