The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"SIR2/SIRT2 'Small Domain'
".
FunFam 7: NAD-dependent protein lipoamidase sirtuin-4, mitoc...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
3 | Q1JQC6 (/ISS) Q8IRR5 (/ISS) Q8R216 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8R216 (/IPI) Q9Y6E7 (/IPI) |
Biotinidase activity GO:0047708
Catalysis of the reaction: biotin amide + H2O = biotin + NH3.
|
2 | Q1JQC6 (/ISS) Q8R216 (/ISS) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q9Y6E7 (/IDA) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q8R216 (/IMP) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q8R216 (/ISO) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q9Y6E7 (/TAS) |
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
1 | Q8IRR5 (/IMP) |
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
|
1 | Q8R216 (/IDA) |
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
|
1 | Q1JQC6 (/ISS) |
Biotinidase activity GO:0047708
Catalysis of the reaction: biotin amide + H2O = biotin + NH3.
|
1 | Q9Y6E7 (/IDA) |
Biotinidase activity GO:0047708
Catalysis of the reaction: biotin amide + H2O = biotin + NH3.
|
1 | Q8R216 (/ISO) |
Lipoamidase activity GO:0061690
Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein.
|
1 | Q9Y6E7 (/IDA) |
Lipoamidase activity GO:0061690
Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein.
|
1 | Q8R216 (/IMP) |
Lipoamidase activity GO:0061690
Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein.
|
1 | Q8R216 (/ISO) |
Lipoamidase activity GO:0061690
Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein.
|
1 | Q1JQC6 (/ISS) |
There are 35 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
2 | B2RZ30 (/IMP) G3V641 (/IMP) |
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
2 | Q8R216 (/IMP) Q9Y6E7 (/IMP) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
2 | Q8R216 (/IMP) Q9Y6E7 (/IMP) |
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
2 | Q1JQC6 (/ISS) Q8R216 (/ISS) |
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | B2RZ30 (/IEP) G3V641 (/IEP) |
Tricarboxylic acid metabolic process GO:0072350
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
|
2 | Q1JQC6 (/ISS) Q9Y6E7 (/ISS) |
Negative regulation of protein processing involved in protein targeting to mitochondrion GO:1903217
Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion.
|
2 | B2RZ30 (/IMP) G3V641 (/IMP) |
Regulation of glutamine family amino acid metabolic process GO:0000820
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
|
1 | Q8R216 (/IMP) |
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q9Y6E7 (/TAS) |
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q8R216 (/IMP) |
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q9Y6E7 (/TAS) |
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
|
1 | Q8R216 (/IMP) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q8R216 (/IDA) |
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
1 | Q9Y6E7 (/TAS) |
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | Q8R216 (/ISO) |
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | Q8IRR5 (/IMP) |
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
|
1 | Q8R216 (/IDA) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q20480 (/HEP) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
1 | Q8R216 (/IDA) |
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
|
1 | Q8R216 (/ISO) |
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q8R216 (/IGI) |
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q8R216 (/ISO) |
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
|
1 | Q8R216 (/IDA) |
Tricarboxylic acid metabolic process GO:0072350
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
|
1 | Q8R216 (/IMP) |
Negative regulation of protein processing involved in protein targeting to mitochondrion GO:1903217
Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion.
|
1 | Q8R216 (/ISO) |
Regulation of pyruvate dehydrogenase activity GO:1904182
Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity.
|
1 | Q9Y6E7 (/IDA) |
Regulation of pyruvate dehydrogenase activity GO:1904182
Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity.
|
1 | Q8R216 (/IMP) |
Regulation of pyruvate dehydrogenase activity GO:1904182
Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity.
|
1 | Q8R216 (/ISO) |
Regulation of pyruvate dehydrogenase activity GO:1904182
Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity.
|
1 | Q1JQC6 (/ISS) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
7 | B2RZ30 (/IDA) G3V641 (/IDA) Q20480 (/IDA) Q20481 (/IDA) Q8IRR5 (/IDA) Q8R216 (/IDA) Q9Y6E7 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | Q1JQC6 (/ISS) Q8IRR5 (/ISS) Q8R216 (/ISS) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
3 | Q1JQC6 (/IDA) Q8R216 (/IDA) Q9Y6E7 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | Q1JQC6 (/ISS) Q8R216 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8R216 (/ISO) |
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | Q8R216 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | Q8R216 (/ISO) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | Q9Y6E7 (/TAS) |