The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: RISC-loading complex subunit TARBP2 isoform X3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) P97473 (/IPI) Q15633 (/IPI)
(4 more)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
12 O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) Q15633 (/IPI) Q15633 (/IPI)
(2 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
12 O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) Q15633 (/IPI) Q15633 (/IPI)
(2 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
12 O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) O75569 (/IPI) Q15633 (/IPI) Q15633 (/IPI)
(2 more)
Pre-miRNA binding GO:0070883
Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
8 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS)
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
4 Q15633 (/TAS) Q15633 (/TAS) Q15633 (/TAS) Q15633 (/TAS)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 Q15633 (/IPI) Q15633 (/IPI) Q15633 (/IPI) Q15633 (/IPI)
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Pre-miRNA binding GO:0070883
Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q4V8C7 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9WTX2 (/ISO)
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
1 P97473 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P97473 (/ISO)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
13 B0V3F8 (/ISS) B0V3F8 (/ISS) P97473 (/ISS) Q0IIG6 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q3SWU0 (/ISS) Q4V8C7 (/ISS) Q7ZYA5 (/ISS)
(3 more)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
12 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) Q15633 (/TAS) Q15633 (/TAS)
(2 more)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
12 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) Q15633 (/TAS) Q15633 (/TAS)
(2 more)
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
8 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
8 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
8 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
8 O75569 (/IMP) O75569 (/IMP) O75569 (/IMP) O75569 (/IMP) O75569 (/IMP) O75569 (/IMP) O75569 (/IMP) O75569 (/IMP)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
4 Q15633 (/TAS) Q15633 (/TAS) Q15633 (/TAS) Q15633 (/TAS)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
4 Q15633 (/IMP) Q15633 (/IMP) Q15633 (/IMP) Q15633 (/IMP)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
MiRNA loading onto RISC involved in gene silencing by miRNA GO:0035280
The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Regulation of viral transcription GO:0046782
Any process that modulates the frequency, rate or extent of the transcription of the viral genome.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Outer ear morphogenesis GO:0042473
The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.
3 Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS)
Middle ear morphogenesis GO:0042474
The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).
3 Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Regulation of viral transcription GO:0046782
Any process that modulates the frequency, rate or extent of the transcription of the viral genome.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
3 Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS)
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
3 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9WTX2 (/IDA)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
1 P97473 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 P97473 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q4V8C7 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q9WTX2 (/ISO)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
1 P97473 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9WTX2 (/IDA)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
1 P97473 (/ISO)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 P97473 (/IMP)
MiRNA loading onto RISC involved in gene silencing by miRNA GO:0035280
The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).
1 P97473 (/ISO)
Outer ear morphogenesis GO:0042473
The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.
1 Q9WTX2 (/IMP)
Middle ear morphogenesis GO:0042474
The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).
1 Q9WTX2 (/IMP)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
1 P97473 (/IMP)
Ear development GO:0043583
The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
1 Q9WTX2 (/IMP)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
1 P97473 (/ISO)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 P97473 (/IMP)
Regulation of viral transcription GO:0046782
Any process that modulates the frequency, rate or extent of the transcription of the viral genome.
1 P97473 (/ISO)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
1 Q9WTX2 (/IMP)
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P97473 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 Q9WTX2 (/ISO)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
1 P97473 (/IMP)
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
1 P97473 (/IDA)
Regulation of production of miRNAs involved in gene silencing by miRNA GO:1903798
Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
1 P97473 (/IMP)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q9WTX2 (/IDA)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 B0V3F8 (/ISS) B0V3F8 (/ISS) P97473 (/ISS) Q0IIG6 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q3SWU0 (/ISS) Q4V8C7 (/ISS) Q7ZYA5 (/ISS)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) O75569 (/TAS) Q15633 (/TAS) Q15633 (/TAS)
(2 more)
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
12 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA) O75569 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA) O75569 (/HDA)
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
7 P97473 (/ISS) Q0IIG6 (/ISS) Q3SWU0 (/ISS) Q4SS66 (/ISS) Q5BJ52 (/ISS) Q6GPZ1 (/ISS) Q7SXR1 (/ISS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
4 Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA) Q15633 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
3 Q2HJ92 (/ISS) Q2HJ92 (/ISS) Q2HJ92 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P97473 (/ISO) Q9WTX2 (/ISO)
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
2 P97473 (/ISO) Q9WTX2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9WTX2 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 P97473 (/ISO)
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