The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phox-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: sorting nexin-27 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
6 A5PKA5 (/ISS) A5PKA5 (/ISS) F3YD98 (/ISS) Q3UHD6 (/ISS) Q9W486 (/ISS) X2JIH1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q3UHD6 (/IPI) Q8K4V4 (/IPI) Q96L92 (/IPI) Q96L92 (/IPI)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
3 Q8K4V4 (/IDA) Q96L92 (/IDA) Q96L92 (/IDA)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
1 Q3UHD6 (/ISO)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 Q8K4V4 (/IPI)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 Q3UHD6 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
6 A5PKA5 (/ISS) A5PKA5 (/ISS) F3YD98 (/ISS) Q3UHD6 (/ISS) Q9W486 (/ISS) X2JIH1 (/ISS)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
4 Q3UHD6 (/IMP) Q8K4V4 (/IMP) Q96L92 (/IMP) Q96L92 (/IMP)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
4 A5PKA5 (/ISS) A5PKA5 (/ISS) Q3UHD6 (/ISS) Q8K4V4 (/ISS)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
3 Q8K4V4 (/IMP) Q96L92 (/IMP) Q96L92 (/IMP)
Establishment of natural killer cell polarity GO:0001770
The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.
2 Q96L92 (/TAS) Q96L92 (/TAS)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 A5PKA5 (/ISS) A5PKA5 (/ISS)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
2 Q96L92 (/IMP) Q96L92 (/IMP)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
1 Q3UHD6 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q8K4V4 (/NAS)
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
1 Q3UHD6 (/IMP)
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
1 Q3UHD6 (/ISO)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
1 Q3UHD6 (/ISO)
Establishment of protein localization to plasma membrane GO:0061951
The directed movement of a protein to a specific location in a plasma membrane.
1 Q8K4V4 (/IMP)
Establishment of protein localization to plasma membrane GO:0061951
The directed movement of a protein to a specific location in a plasma membrane.
1 Q3UHD6 (/ISO)
Endosome to plasma membrane protein transport GO:0099638
The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.
1 Q8K4V4 (/IMP)
Endosome to plasma membrane protein transport GO:0099638
The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.
1 Q3UHD6 (/ISO)
Negative regulation of inward rectifier potassium channel activity GO:1903609
Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.
1 Q8K4V4 (/IDA)
Negative regulation of inward rectifier potassium channel activity GO:1903609
Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.
1 Q3UHD6 (/ISO)
Response to methamphetamine hydrochloride GO:1904313
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus.
1 Q8K4V4 (/IEP)
Positive regulation of AMPA glutamate receptor clustering GO:1904719
Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering.
1 Q8K4V4 (/IMP)
Positive regulation of AMPA glutamate receptor clustering GO:1904719
Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering.
1 Q3UHD6 (/ISO)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 Q8K4V4 (/IEP)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
1 Q3UHD6 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
5 A5PKA5 (/ISS) A5PKA5 (/ISS) F3YD98 (/ISS) Q9W486 (/ISS) X2JIH1 (/ISS)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
4 A5PKA5 (/ISS) A5PKA5 (/ISS) Q3UHD6 (/ISS) Q8K4V4 (/ISS)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 Q3UHD6 (/IDA) Q8K4V4 (/IDA) Q96L92 (/IDA) Q96L92 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q8K4V4 (/IDA) Q96L92 (/IDA) Q96L92 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
2 Q96L92 (/IDA) Q96L92 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q96L92 (/IDA) Q96L92 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q96L92 (/IC) Q96L92 (/IC)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q3UHD6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q3UHD6 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q3UHD6 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q3UHD6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q3UHD6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8K4V4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q3UHD6 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q8K4V4 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q3UHD6 (/ISO)
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