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CATH Superfamily 3.30.1490.20

ATP-grasp fold, A domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: N5-carboxyaminoimidazole ribonucleotide synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5-(carboxyamino)imidazole ribonucleotide synthase. [EC: 6.3.4.18]
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
  • In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates.
  • Carboxyphosphate is the putative acyl phosphate intermediate.
  • Involved in the late stages of purine biosynthesis.
 101 A0A0E4CKP3 A0A0E4CKP3 A0A0E4CKP3 A0A0E4CKP3 A0A0E4CKP3 A0A0E4CKP3 A0A0H3AKH5 A0A0H3AKH5 A0A0H3AKH5 A0A0H3AKH5
(91 more...)
Phosphoribosylaminoimidazole carboxylase. [EC: 4.1.1.21]
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
 1 Q54QE4
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [EC: 6.3.2.6]
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
  • Forms part of the purine biosynthesis pathway.
 1 Q54QE4
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