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CATH Superfamily 3.30.1370.170

Erythronate-4-phosphate dehydrogenase, dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Erythronate-4-phosphate dehydrogenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
  • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
  • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
  • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
  • Cf. EC 1.1.1.399.
 9 A0A0H3PZR6 A0A0H3PZR6 A0A0H3PZR6 A0A0H6MEZ1 A0A0H6MEZ1 A0A0H6MEZ1 Q9KQ92 Q9KQ92 Q9KQ92
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