The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
MHCK/EF2 kinase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Eukaryotic elongation factor 2 kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
5 P42527 (/IC) P90648 (/IC) Q54DK4 (/IC) Q54SF9 (/IC) Q8MY12 (/IC)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 P42527 (/IDA) P90648 (/IDA) Q8MY12 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 Q54DK4 (/ISS) Q54SF9 (/ISS) Q8MY12 (/ISS)
Elongation factor-2 kinase activity GO:0004686
Catalysis of the reaction: ATP +
3 O00418 (/IDA) O01991 (/IDA) O08796 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 O00418 (/IDA) O08796 (/IDA)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
2 O00418 (/TAS) O08796 (/TAS)
Myosin heavy chain kinase activity GO:0016905
Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate.
2 P42527 (/IDA) P90648 (/IDA)
Myosin II binding GO:0045159
Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
2 P42527 (/IPI) P90648 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P42527 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 O00418 (/TAS)
Elongation factor-2 kinase activity GO:0004686
Catalysis of the reaction: ATP +
1 P70531 (/IMP)
Elongation factor-2 kinase activity GO:0004686
Catalysis of the reaction: ATP +
1 O08796 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P42527 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 O08796 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 P70531 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P42527 (/IDA)
Myosin heavy chain kinase activity GO:0016905
Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate.
1 Q8MY12 (/IMP)
Myosin heavy chain kinase activity GO:0016905
Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate.
1 Q54SF9 (/ISS)
Myosin II binding GO:0045159
Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
1 Q8MY12 (/ISS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P42527 (/IDA)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Myosin II filament disassembly GO:0031037
The disassembly of a bipolar filament composed of myosin II molecules.
4 P42527 (/IMP) P90648 (/IMP) Q54SF9 (/IMP) Q8MY12 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
3 P42527 (/IMP) P90648 (/IMP) Q8MY12 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 Q54DK4 (/ISS) Q54SF9 (/ISS) Q8MY12 (/ISS)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
3 P42527 (/IDA) P90648 (/IDA) Q8MY12 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 O00418 (/IDA) P42527 (/IDA) P90648 (/IDA)
Response to differentiation-inducing factor 1 GO:1903013
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus.
3 P90648 (/HDA) Q54SF9 (/HDA) Q8MY12 (/HDA)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
2 O00418 (/TAS) O08796 (/TAS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 O01991 (/IDA) P42527 (/IDA)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
2 P42527 (/IMP) Q8MY12 (/IMP)
Cerebellum vasculature development GO:0061300
The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure.
2 E7F318 (/IGI) Q6DGE0 (/IGI)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 P70531 (/IEP)
Myosin II filament disassembly GO:0031037
The disassembly of a bipolar filament composed of myosin II molecules.
1 P42527 (/IDA)
Regulation of protein autophosphorylation GO:0031952
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
1 O08796 (/IDA)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P70531 (/IEP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P70531 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O08796 (/ISO)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 P70531 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 O08796 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 O08796 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P70531 (/ISS)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 P42527 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P42527 (/IDA)
Actin crosslink formation GO:0051764
The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
1 P42527 (/IDA)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P70531 (/IMP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O08796 (/ISO)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 P70531 (/IMP)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 O08796 (/ISO)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 P70531 (/IEP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P70531 (/IEP)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
1 P70531 (/IEP)
Cellular response to brain-derived neurotrophic factor stimulus GO:1990416
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
1 P70531 (/IEP)
Response to prolactin GO:1990637
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.
1 P70531 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P42527 (/IDA) P90648 (/IDA)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
2 P90648 (/IDA) Q8MY12 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
2 P42527 (/IDA) Q8MY12 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O00418 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O00418 (/TAS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P70531 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 O08796 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P70531 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 O08796 (/ISO)
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