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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 71: Hydroxymethylglutaryl-CoA lyase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydroxymethylglutaryl-CoA lyase. [EC: 4.1.3.4]
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.
    		 80 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A0H2Z956 A0A0H2Z956
    (70 more...)
    3-hydroxy-3-isohexenylglutaryl-CoA lyase. [EC: 4.1.3.26]
    3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6- enoyl-CoA + acetate.
    • Also acts on the hydroxy derivative of farnesoyl-CoA.
    		 64 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A077JUJ9 A0A0H2Z956 A0A0H2Z956
    (54 more...)
    (R)-citramalyl-CoA lyase. [EC: 4.1.3.46]
    (3R)-citramalyl-CoA = acetyl-CoA + pyruvate.
    • The enzyme, purified from the bacterium Chloroflexus aurantiacus, has no activity with (3S)-citramalyl-CoA (cf. EC 4.1.3.25).
    		 1 A9WGE2
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