The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: Triosephosphate isomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Triose-phosphate isomerase activity GO:0004807
Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
28 B0BM40 (/ISS) O77458 (/ISS) O77458 (/ISS) P00940 (/ISS) P15426 (/ISS) P15426 (/ISS) P29613 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS)
(18 more)
Methylglyoxal synthase activity GO:0008929
Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate.
28 B0BM40 (/ISS) P00940 (/ISS) P15426 (/ISS) P15426 (/ISS) P17751 (/ISS) P48500 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS)
(18 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
26 B0BM40 (/ISS) P00939 (/ISS) P00940 (/ISS) P15426 (/ISS) P15426 (/ISS) P17751 (/ISS) P48500 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS)
(16 more)
Triose-phosphate isomerase activity GO:0004807
Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
22 P00939 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA)
(12 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P48500 (/IPI) P60174 (/IPI) P60174 (/IPI) P60174 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P29613 (/IDA) P60174 (/IDA) P60174 (/IDA) P60174 (/IDA)
Triose-phosphate isomerase activity GO:0004807
Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
3 P60174 (/NAS) P60174 (/NAS) P60174 (/NAS)
Triose-phosphate isomerase activity GO:0004807
Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
3 P60174 (/TAS) P60174 (/TAS) P60174 (/TAS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
3 P60174 (/IPI) P60174 (/IPI) P60174 (/IPI)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 P48491 (/IDA) P48491 (/IDA)
Showing 1 to 10 of 19 entries

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Methylglyoxal biosynthetic process GO:0019242
The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
28 B0BM40 (/ISS) P00940 (/ISS) P15426 (/ISS) P15426 (/ISS) P17751 (/ISS) P48500 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS)
(18 more)
Glyceraldehyde-3-phosphate biosynthetic process GO:0046166
The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.
25 B0BM40 (/ISS) P00940 (/ISS) P15426 (/ISS) P15426 (/ISS) P17751 (/ISS) P48500 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS) P54714 (/ISS)
(15 more)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
11 P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP) P00942 (/IMP)
(1 more)
Glyceraldehyde-3-phosphate biosynthetic process GO:0046166
The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.
6 P00939 (/IDA) P60174 (/IDA) P60174 (/IDA) P60174 (/IDA) Q9SKP6 (/IDA) Q9SKP6 (/IDA)
Glyceraldehyde-3-phosphate metabolic process GO:0019682
The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis.
5 O77458 (/ISS) O77458 (/ISS) P29613 (/ISS) Q7JNS1 (/ISS) Q7JNS1 (/ISS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
4 P00940 (/TAS) P60174 (/TAS) P60174 (/TAS) P60174 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
3 P17751 (/IC) P48491 (/IC) P48491 (/IC)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 A0A060VUA9 (/IDA) A0A060XMI6 (/IDA) Q70I40 (/IDA)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
3 P60174 (/TAS) P60174 (/TAS) P60174 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
2 P00940 (/TAS) P48500 (/TAS)
Showing 1 to 10 of 44 entries

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
14 P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA) P00942 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA) P00942 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P48491 (/IDA) P48491 (/IDA) P48500 (/IDA) Q6FRI3 (/IDA) Q6FRI3 (/IDA) Q9SKP6 (/IDA) Q9SKP6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P00940 (/TAS) P60174 (/TAS) P60174 (/TAS) P60174 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 P48491 (/IDA) P48491 (/IDA) Q9SKP6 (/IDA) Q9SKP6 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
4 P48491 (/IDA) P48491 (/IDA) Q9SKP6 (/IDA) Q9SKP6 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
4 P48491 (/IDA) P48491 (/IDA) Q9SKP6 (/IDA) Q9SKP6 (/IDA)
Showing 1 to 10 of 28 entries
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