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CATH Superfamily 3.20.20.60

Phosphoenolpyruvate-binding domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphoenolpyruvate-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 86: Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyas...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malyl-CoA lyase. [EC: 4.1.3.24]
(1) (S)-malyl-CoA = acetyl-CoA + glyoxylate. (2) (2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate.
  • The enzymes from Rhodobacter species catalyze a step in the ethylmalonyl-CoA pathway for acetate assimilation.
  • The enzyme from halophilic bacteria participate in the methylaspartate cycle and catalyze the reaction in the direction of malyl-CoA formation.
  • The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25.
 4 A9WC35 A9WC35 S5N020 S5N020
(S)-citramalyl-CoA lyase. [EC: 4.1.3.25]
(3S)-citramalyl-CoA = acetyl-CoA + pyruvate.
  • The enzyme from the bacterium Clostridium tetanomorphum is a component of EC 4.1.3.22.
  • It also acts on (3S)-citramalyl thioacyl-carrier protein.
  • The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC 4.1.3.24.
  • It has no activity with (3R)-citramalyl-CoA (cf. EC 4.1.3.46).
 4 A9WC35 A9WC35 S5N020 S5N020
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