The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Malate synthase, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: Malate synthase G

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
20 P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA)
(10 more)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
10 P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI)
Malate synthase activity GO:0004474
Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
10 P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
10 P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
10 P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI) P9WK17 (/IPI)
Host cell extracellular matrix binding GO:0046810
Interacting selectively and non-covalently with the extracellular matrix of a host cell.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Malate synthase activity GO:0004474
Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
5 Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adhesion of symbiont to host GO:0044406
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
12 I7FMS9 (/IDA) I7FMS9 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
(2 more)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
10 P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA) P9WK16 (/IDA)
Coenzyme A metabolic process GO:0015936
The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
5 Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS) Q4K4S5 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
30 A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA) A5U3K4 (/IDA)
(20 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
10 P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
10 P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA) P9WK17 (/HDA)
Capsule GO:0042603
A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication.
10 P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA) P9WK17 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...