The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Methylenetetrahydrofolate reductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylenetetrahydrofolate reductase (NAD(P)H) activity GO:0004489
Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
105 P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA)
(95 more)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
105 P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA)
(95 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
105 P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA)
(95 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
105 P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA) P0AEZ1 (/IDA)
(95 more)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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