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CATH Superfamily 3.20.20.190

Phosphatidylinositol (PI) phosphodiesterase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol (PI) phosphodiesterase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Glycerophosphodiester phosphodiesterase, periplasmicGlycerophosphoryl diester phosphodiesteraseGlycerophosphodiester phosphodiesterase, cytosolicSC:21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase1-phosphatidylinositol 4,5-bisphosphate phosphodiesterasePhosphoinositide phospholipase C1-phosphatidylinositol phosphodiesterasePhosphoinositide phospholipase CPhosphoinositide phospholipase C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma1-phosphatidylinositol 4,5-bisphosphate phosphodiesterasePhosphoinositide phospholipase C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPhosphoinositide phospholipase CPhosphoinositide phospholipase CGlycerophosphodiester phosphodiesterase GDPDL31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaGlycerophosphodiester phosphodiesterase GDPDL3Glycerophosphocholine phosphodiesterase GPCPD11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaglycerophosphodiester phosphodiesterase domain-containing protein 1Phosphoinositide phospholipase CPhosphoinositide phospholipase CPI-PLC X domain-containing protein 3Phosphoinositide phospholipase CGlycerophosphodiester phosphodiesterase GDPD5Glycerophosphodiester phosphodiesterase gde1Phosphoinositide phospholipase CPhosphoinositide phospholipase CGlycerophosphodiester phosphodiesterase domain-containing protein 5Glycerophosphodiester phosphodiesterase 1 isoform X11-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseGlycerophosphoryl diester phosphodiesterase, putativeGlycerophosphodiester phosphodiesterase domain containing 3Glycerophosphodiester phosphodiesterase GDPD2Phosphoinositide phospholipase CPhosphoinositide phospholipase CUncharacterized protein, isoform CPhosphoinositide phospholipase CGlycerophosphoryl diester phosphodiesterase family proteinGlycerophosphocholine phosphodiesterase GPCPD1Glycerophosphodiester phosphodiesterase1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPhosphoinositide phospholipase CGlycerophosphodiester phosphodiesterasePhosphoinositide phospholipase CPhosphoinositide phospholipase CPI-PLC X domain-containing proteinPhosphoinositide phospholipase CGlycerophosphoryl diester phosphodiesteraseDNA-(Apurinic or apyrimidinic site) lyase 21-phosphatidylinositol 4,5-bisphosphate phosphodiesterasePhosphoinositide phospholipase CPhosphoinositide phospholipase CPhosphoinositide phospholipase CAnkyrin repeat protein nuc-2Phosphoinositide phospholipase CPgc1pGlycerophosphodiester phosphodiesterase domain containing 1Phosphoinositide phospholipase CPhosphoinositide phospholipase C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPhosphoinositide phospholipase CPhosphoinositide phospholipase CPhosphoinositide phospholipase CGlycerophosphoryl diester phosphodiesterase family, putativePutative glycerophosphoryl diester phosphodiesterasePhosphoinositide phospholipase CPhosphoinositide phospholipase Cglycerophosphocholine phosphodiesterase GPCPD1Phosphoinositide phospholipase CWGS project CABT00000000 data, contig 2.28Phosphatidylinositol-specific phospholipase c, putativePhosphoinositide phospholipase CPhosphoinositide phospholipase CPhosphoinositide-specific phospholipase C, efhand-like/Phosphatidylinositol-specific phospholipase C, X domain/PDZ domain (Also known as DHR or GLGF)/PDZ domain containing protein, putativeGM14906POGO family transposase, putativeGlycerophosphoryl diester phosphodiesterase, putativeGlycosylphosphatidylinositol-specific phospholipase C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPhosphoinositide phospholipase CUncharacterized proteinGlycerophosphodiester phosphodiesterase, putativePhospholipase DPhosphoinositide phospholipase CPhosphoinositide phospholipase CPhosphoinositide phospholipase C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPhosphoinositide phospholipase CUncharacterized proteinPhospholipase D LiSicTox-betaID1Uncharacterized proteinUncharacterized proteinPredicted proteinGlycerophosphoryl diester phosphodiesteraseGlycerophosphoryl diester phosphodiesterase family proteinUncharacterized proteinUncharacterized proteinFI16509p1Phosphate system positive regulatory protein, putative
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FunFam 27: Phosphoinositide phospholipase C

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
Phosphoinositide phospholipase C. [EC: 3.1.4.11]
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
  • These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3).
  • They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
 10 A0A140VJR9 A0A140VJR9 Q1RML2 Q2VRL0 Q5FX52 Q7YRU3 Q86YW0 Q86YW0 Q8K4D7 Q95JS1
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