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CATH Superfamily 3.20.20.105

Queuine tRNA-ribosyltransferase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Queuine tRNA-ribosyltransferase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Queuine tRNA-ribosyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA-guanine(34) transglycosylase. [EC: 2.4.2.29]
(1) Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine. (2) Guanine(34) in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7- carbaguanine(34) in tRNA + guanine.
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine.
  • In eubacteria, which produce queuine de novo, the enzyme catalyzes the exchange of guanine with the queuine precursor preQ(1), which is ultimately modified to queuine.
  • The eubacterial enzyme can also use an earlier intermediate, preQ(0), to replace guanine in unmodified tRNA(Tyr) and tRNA(Asn).
  • This enzyme acts after EC 1.7.1.13 in the queuine-biosynthesis pathway.
 16 A0A0M1L2Q7 A0A0M1L2Q7 A0A0M1L2Q7 A0A0M1L2Q7 A0A175M9B0 A0A175M9B0 A0A175M9B0 A0A175M9B0 A5I6E9 A5I6E9
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