The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Aldo-keto reductase family 1 member A1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-glucuronate reductase activity GO:0047939
Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
6 P14550 (/IDA) P14550 (/IDA) P14550 (/IDA) P51635 (/IDA) Q9JII6 (/IDA) Q9JII6 (/IDA)
Glucuronolactone reductase activity GO:0047941
Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH.
6 P14550 (/IDA) P14550 (/IDA) P14550 (/IDA) P51635 (/IDA) Q9JII6 (/IDA) Q9JII6 (/IDA)
Alditol:NADP+ 1-oxidoreductase activity GO:0004032
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
5 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS) Q9JII6 (/TAS) Q9JII6 (/TAS)
L-glucuronate reductase activity GO:0047939
Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
5 O70473 (/ISS) O70473 (/ISS) P50578 (/ISS) Q3ZCJ2 (/ISS) Q5R5D5 (/ISS)
Glucuronolactone reductase activity GO:0047941
Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH.
5 O70473 (/ISS) O70473 (/ISS) P50578 (/ISS) Q3ZCJ2 (/ISS) Q5R5D5 (/ISS)
Alditol:NADP+ 1-oxidoreductase activity GO:0004032
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
4 Q9JII6 (/ISS) Q9JII6 (/ISS) Q9VHX4 (/ISS) Q9VTL0 (/ISS)
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P14550 (/IPI) P14550 (/IPI) P14550 (/IPI)
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
L-glucuronate reductase activity GO:0047939
Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
3 P14550 (/EXP) P14550 (/EXP) P14550 (/EXP)
Alditol:NADP+ 1-oxidoreductase activity GO:0004032
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
Alcohol dehydrogenase (NADP+) activity GO:0008106
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.
2 Q9JII6 (/NAS) Q9JII6 (/NAS)
L-glucuronate reductase activity GO:0047939
Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
2 Q9JII6 (/IMP) Q9JII6 (/IMP)
L-glucuronate reductase activity GO:0047939
Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
Glucuronolactone reductase activity GO:0047941
Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
1 P74308 (/IDA)
Indanol dehydrogenase activity GO:0047718
Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+.
1 M9PF61 (/ISS)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 P74308 (/IDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
13 O70473 (/ISS) O70473 (/ISS) P14550 (/ISS) P14550 (/ISS) P14550 (/ISS) P50578 (/ISS) Q28FD1 (/ISS) Q3ZCJ2 (/ISS) Q568L5 (/ISS) Q5R5D5 (/ISS)
(3 more)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
Glucuronate catabolic process to xylulose 5-phosphate GO:0019640
The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
3 P51635 (/IMP) Q9JII6 (/IMP) Q9JII6 (/IMP)
Daunorubicin metabolic process GO:0044597
The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
3 P14550 (/IDA) P14550 (/IDA) P14550 (/IDA)
Doxorubicin metabolic process GO:0044598
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
3 P14550 (/IDA) P14550 (/IDA) P14550 (/IDA)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
2 Q8T492 (/IMP) Q9VTL0 (/IMP)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
2 P50578 (/ISS) Q3ZCJ2 (/ISS)
D-glucuronate catabolic process GO:0042840
The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
D-glucuronate catabolic process GO:0042840
The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
D-glucuronate catabolic process GO:0042840
The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.
2 P50578 (/ISS) Q3ZCJ2 (/ISS)
Daunorubicin metabolic process GO:0044597
The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
Doxorubicin metabolic process GO:0044598
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
Aldehyde catabolic process GO:0046185
The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
2 Q9JII6 (/IMP) Q9JII6 (/IMP)
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
2 Q9JII6 (/ISO) Q9JII6 (/ISO)
D-glucuronate catabolic process GO:0042840
The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.
1 P51635 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P74308 (/IDA)
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
1 P51635 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 O70473 (/ISS) O70473 (/ISS) P14550 (/ISS) P14550 (/ISS) P14550 (/ISS) P50578 (/ISS) P51635 (/ISS) Q28FD1 (/ISS) Q3ZCJ2 (/ISS) Q568L5 (/ISS)
(4 more)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
14 O70473 (/ISS) O70473 (/ISS) P14550 (/ISS) P14550 (/ISS) P14550 (/ISS) P50578 (/ISS) P51635 (/ISS) Q28FD1 (/ISS) Q3ZCJ2 (/ISS) Q568L5 (/ISS)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 M9PF61 (/HDA) M9PI17 (/HDA) Q8IQF8 (/HDA) Q9VTK9 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 M9PF61 (/HDA) M9PI17 (/HDA) Q8IQF8 (/HDA) Q9VTK9 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P14550 (/HDA) P14550 (/HDA) P14550 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P14550 (/TAS) P14550 (/TAS) P14550 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P14550 (/HDA) P14550 (/HDA) P14550 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 Q9JII6 (/EXP) Q9JII6 (/EXP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 Q9JII6 (/IDA) Q9JII6 (/IDA)
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