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CATH Superfamily 3.20.19.10

Aconitase, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Isopropylmalate/citramalate isomerase small subuni...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-isopropylmalate dehydratase. [EC: 4.2.1.33]
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
  • Forms part of the leucine-biosynthesis pathway.
  • Brings about the interconversion of the two isomers of isopropylmalate.
 10 A0A178VZE1 A0A178VZE1 A0A178W1Y9 A0A178W1Y9 Q58673 Q9LYT7 Q9ZW84 Q9ZW84 Q9ZW85 Q9ZW85
Dimethylmaleate hydratase. [EC: 4.2.1.85]
(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O.
  • Inhibited by oxygen.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC 1.17.5.1, EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6 and EC 4.1.3.32.
 4 A0A1H3FZA4 A0A1H3FZA4 Q0QLE1 Q0QLE1
Maleate hydratase. [EC: 4.2.1.31]
(R)-malate = maleate + H(2)O.
    		 1 Q58673
    (R)-2-methylmalate dehydratase. [EC: 4.2.1.35]
    (R)-2-methylmalate = 2-methylmaleate + H(2)O.
      		 1 Q58673
      Methanogen homoaconitase. [EC: 4.2.1.114]
      (R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4- tricarboxylate.
      • Catalyzes several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
      • In contrast to EC 4.2.1.36, this enzyme can catalyze both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate.
      • In addition to cis-homoaconitate, the enzyme can also catalyze the hydration of the physiological substrates dihomocitrate and trihomocitrate as well as the non-physiological substrate tetrahomocitrate.
      • Cis-aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.
      		 1 Q58667
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