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CATH Superfamily 3.20.19.10

Aconitase, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Aconitate hydratase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aconitate hydratase. [EC: 4.2.1.3]
Citrate = isocitrate.
  • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
  • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
  • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
  • Formerly EC 4.2.1.4.
 2 Q8EJW3 Q937N8
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming). [EC: 4.2.1.117]
(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H(2)O.
  • Catalyzes the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer).
  • Part of a propanoate degradation pathway.
  • The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher.
  • 2-methylisocitrate and isocitrate were not substrates.
 1 Q8EJW3
2-methylisocitrate dehydratase. [EC: 4.2.1.99]
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
  • The enzyme from the fungus Yarrowia lipolytica does not act on isocitrate.
 1 Q937N8
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