The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Antimicrobial Peptide, Beta-defensin 2; Chain A
".
FunFam 1: Beta-defensin 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
CCR6 chemokine receptor binding GO:0031731
Interacting selectively and non-covalently with a CCR6 chemokine receptor.
|
68 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(58 more) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O15263 (/IPI) P82019 (/IPI) P82019 (/IPI) |
CCR6 chemokine receptor binding GO:0031731
Interacting selectively and non-covalently with a CCR6 chemokine receptor.
|
3 | O15263 (/IDA) P82019 (/IDA) P82019 (/IDA) |
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
|
1 | Q7TNV9 (/IDA) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
72 |
A3FPG7 (/ISS)
A3FPG7 (/ISS)
A3FPG7 (/ISS)
D0F1S0 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
(62 more) |
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
68 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(58 more) |
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Calcium-mediated signaling using intracellular calcium source GO:0035584
A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Positive regulation of flagellated sperm motility involved in capacitation GO:0060474
The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
20 |
O15263 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
(10 more) |
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
16 |
O15263 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
P81534 (/IMP)
(6 more) |
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
15 |
O15263 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
(5 more) |
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
|
13 |
O15263 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
(3 more) |
Killing of cells of other organism GO:0031640
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
|
13 |
O15263 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
(3 more) |
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
5 | Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
5 | Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) Q95J24 (/ISS) |
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
4 | O88514 (/ISS) Q9BDS9 (/ISS) Q9TT12 (/ISS) Q9TT12 (/ISS) |
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
3 | O15263 (/IDA) P82019 (/IDA) P82019 (/IDA) |
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
3 | P82019 (/ISO) P82019 (/ISO) Q7TNV9 (/ISO) |
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
2 | Q7TNV9 (/IDA) Q91V82 (/IDA) |
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
|
1 | O89117 (/IEP) |
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | O15263 (/TAS) |
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | O15263 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | O15263 (/TAS) |
Killing of cells of other organism GO:0031640
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
|
1 | O15263 (/IMP) |
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
1 | O89117 (/IEP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q32ZI5 (/IDA) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q91V82 (/IMP) |
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | Q91V82 (/IMP) |
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
1 | Q91V82 (/IMP) |
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | Q7TNV9 (/IDA) |
Antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844
An immune response against microbes mediated by anti-microbial peptides in body fluid.
|
1 | O15263 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Sperm midpiece GO:0097225
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Microvesicle GO:1990742
An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm.
|
64 |
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O18794 (/ISS)
O19038 (/ISS)
O19038 (/ISS)
(54 more) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
19 |
A0A0N9WLX3 (/IDA)
A0A0N9WLX3 (/IDA)
A0A0N9WLX3 (/IDA)
O15263 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
P81534 (/IDA)
(9 more) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
13 |
O15263 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
(3 more) |
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
|
13 |
O15263 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
P81534 (/TAS)
(3 more) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
6 | A0A0N9WLX3 (/IDA) A0A0N9WLX3 (/IDA) A0A0N9WLX3 (/IDA) Q6QLR1 (/IDA) Q6QLR1 (/IDA) Q6QLR1 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P82019 (/ISO) P82019 (/ISO) Q7TNV9 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q6QLR1 (/IDA) Q6QLR1 (/IDA) Q6QLR1 (/IDA) |
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | P46170 (/IDA) |