The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SRCR-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Deleted in malignant brain tumors 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
30 Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q95218 (/ISS) Q95218 (/ISS)
(20 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q60997 (/IPI) Q9UGM3 (/IPI) Q9UGM3 (/IPI)
(12 more)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
14 Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS)
(4 more)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Signaling pattern recognition receptor activity GO:0008329
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
8 Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA) Q60997 (/RCA)
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
30 Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q95218 (/ISS) Q95218 (/ISS)
(20 more)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
30 Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q95218 (/ISS) Q95218 (/ISS)
(20 more)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
14 Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS) Q9UGM3 (/NAS)
(4 more)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Induction of bacterial agglutination GO:0043152
Any process in which infecting bacteria are clumped together by a host organism.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Blastocyst development GO:0001824
The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
8 Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP) Q60997 (/IMP)
Inner cell mass cell proliferation GO:0001833
The proliferation of cells in the inner cell mass.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
8 Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP) Q60997 (/IEP)
Positive regulation of epithelial cell differentiation GO:0030858
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
4 Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
4 Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
4 Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
4 Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
4 Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP) Q8CIZ5 (/IEP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
30 Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q95218 (/ISS) Q95218 (/ISS)
(20 more)
Zymogen granule membrane GO:0042589
The lipid bilayer surrounding a zymogen granule.
30 Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q4A3R3 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q8CIZ5 (/ISS) Q95218 (/ISS) Q95218 (/ISS)
(20 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
14 Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS) Q9UGM3 (/TAS)
(4 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
14 Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
14 Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA)
(4 more)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
14 Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA) Q9UGM3 (/IDA)
(4 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
14 Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA) Q9UGM3 (/HDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
8 Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Zymogen granule membrane GO:0042589
The lipid bilayer surrounding a zymogen granule.
8 Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA) Q60997 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
8 Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA) Q60997 (/HDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
8 Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO) Q60997 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
4 Q8CIZ5 (/IDA) Q8CIZ5 (/IDA) Q8CIZ5 (/IDA) Q8CIZ5 (/IDA)
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