CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 143: E3 ubiquitin-protein ligase UHRF1 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8VDF2 (/IPI) Q96T88 (/IPI) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q96T88 (/IDA) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q8VDF2 (/ISO) |
Showing 1 to 10 of 26 entries
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
3 | E7EZF3 (/IMP) Q8VDF2 (/IMP) Q96T88 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8VDF2 (/ISO) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | E7EZF3 (/IGI) |
Showing 1 to 10 of 33 entries
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q96T88 (/ISS) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | A0A087WTW0 (/IDA) A0A087WVR3 (/IDA) Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8VDF2 (/ISO) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
1 | Q96T88 (/IDA) |
Showing 1 to 10 of 23 entries
