View in Gene3D

CATH Superfamily 3.10.110.10

Ubiquitin Conjugating Enzyme

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 33: NEDD8-conjugating enzyme UBE2F

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cullin-RING-type E3 NEDD8 transferase. [EC: 2.3.2.32]
S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]- L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8- protein]-yl-[cullin]-L-lysine.
  • Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly.
  • Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING- Ligase.
  • The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation.
  • The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex.
  • The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family.
 242 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971 A0A096N971
(232 more...)
CATH-Gene3D is a Global Biodata Core Resource Learn more...