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CATH Superfamily 2.70.40.10

Deoxyuridine triphosphatase (dUTPase)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Deoxyuridine triphosphatase (dUTPase)

This entry represents a distorted barrel domain found in deoxyuridine triphosphate nucleotidohydrolases and CTP deaminases. Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) cleaves dUTP into pyrophosphate and dUMP. Three different subunit organisations of dUTPases have been found: they are either monomers, dimers or trimers PMID:11375495. In the homotrimer, each subunit folds into a twisted antiparallel beta-barrel with the N and C-terminal portions interacting with adjacent subunits PMID:9878436.

PMID:11375495 PMID:9878436 (INTERPRO:IPR036157)

GO Diversity

Unique GO annotations
37 Unique GO terms

EC Diversity

Unique EC annotations
9 Unique EC terms

Species Diversity

Unique species annotations
17059 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 437
Domain clusters (>95% seq id): 42
Domain clusters (>35% seq id): 21
Unique PDBs: 150
Alignments
Structural Clusters (5A): 3
Structural Clusters (9A): 3
FunFam Clusters: 37
Function
Unique EC: 9
Unique GO: 37
Taxonomy
Unique Species: 17059
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