The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Glycine receptor alpha 1 subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 25 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellularly glycine-gated chloride channel activity GO:0016934
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
27 F1Q832 (/IDA) F1QJA0 (/IDA) F1RDZ6 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(17 more)
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
21 A0A2R8Q3D5 (/IDA) A0A2R8Q5V1 (/IDA) A0A2R8Q8T1 (/IDA) A0A2R8QBE2 (/IDA) A0A2R8QMY9 (/IDA) B3DJL8 (/IDA) D1KZ66 (/IDA) F1Q832 (/IDA) F1Q835 (/IDA) F1QCW4 (/IDA)
(11 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
20 A0A2R8Q3D5 (/IDA) A0A2R8Q5V1 (/IDA) A0A2R8Q8T1 (/IDA) A0A2R8QBE2 (/IDA) A0A2R8QMY9 (/IDA) B3DJL8 (/IDA) D1KZ66 (/IDA) F1Q832 (/IDA) F1Q835 (/IDA) F1QCW4 (/IDA)
(10 more)
Glycine-gated chloride ion channel activity GO:0022852
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts.
12 O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(2 more)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
9 O93430 (/IDA) O93430 (/IDA) P07727 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA) P23416 (/IDA) Q64018 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
5 O93430 (/ISS) O93430 (/ISS) P07727 (/ISS) P57695 (/ISS) Q64018 (/ISS)
Extracellularly glycine-gated chloride channel activity GO:0016934
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
5 P23415 (/IMP) P23415 (/IMP) P23415 (/IMP) P23415 (/IMP) Q64018 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P23415 (/IPI) P23415 (/IPI) P23415 (/IPI) P23415 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 P23415 (/IMP) P23415 (/IMP) P23415 (/IMP) P23415 (/IMP)
Extracellularly glycine-gated chloride channel activity GO:0016934
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
4 Q64018 (/ISO) Q7TNC8 (/ISO) Q7TNC8 (/ISO) Q91XP5 (/ISO)
Showing 1 to 10 of 25 entries

There are 72 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
18 O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(8 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
16 O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS)
(6 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
14 O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(4 more)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
10 F1Q832 (/IMP) F1QJA0 (/IMP) F1RDZ6 (/IMP) P23415 (/IMP) P23415 (/IMP) P23415 (/IMP) P23415 (/IMP) Q5CZW5 (/IMP) Q64018 (/IMP) Q9DES9 (/IMP)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 F1Q832 (/IDA) F1QJA0 (/IDA) F1RDZ6 (/IDA) P07727 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA) Q5CZW5 (/IDA) Q9DES9 (/IDA)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
8 F1Q832 (/IDA) F1QJA0 (/IDA) F1RDZ6 (/IDA) O93430 (/IDA) O93430 (/IDA) Q5CZW5 (/IDA) Q61603 (/IDA) Q9DES9 (/IDA)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
7 F1Q832 (/IMP) F1QJA0 (/IMP) F1RDZ6 (/IMP) O93430 (/IMP) O93430 (/IMP) Q5CZW5 (/IMP) Q9DES9 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
7 F1Q832 (/IMP) F1QJA0 (/IMP) F1RDZ6 (/IMP) O93430 (/IMP) O93430 (/IMP) Q5CZW5 (/IMP) Q9DES9 (/IMP)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 O93430 (/IDA) O93430 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA) P23415 (/IDA)
Inhibitory postsynaptic potential GO:0060080
A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
6 P07727 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P57695 (/ISS)
Showing 1 to 10 of 72 entries

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
18 O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(8 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS) O75311 (/TAS)
(6 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
15 O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP) O75311 (/IMP)
(5 more)
Glycine-gated chloride channel complex GO:0016935
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
11 O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA) O75311 (/IDA)
(1 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
7 O93430 (/ISS) O93430 (/ISS) P07727 (/ISS) P24524 (/ISS) P57695 (/ISS) Q64018 (/ISS) Q91XP5 (/ISS)
Glycinergic synapse GO:0098690
A synapse that uses glycine as a neurotransmitter.
7 P07727 (/IDA) P24524 (/IDA) Q61603 (/IDA) Q64018 (/IDA) Q7TNC8 (/IDA) Q7TNC8 (/IDA) Q91XP5 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
6 P07727 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P57695 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
6 P07727 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P57695 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
6 P07727 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P23415 (/ISS) P57695 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q64018 (/ISO) Q7TNC8 (/ISO) Q7TNC8 (/ISO) Q91XP5 (/ISO)
Showing 1 to 10 of 33 entries
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