The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Nicotinic acetylcholine receptor subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
34 E1JJR2 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) Q60S81 (/ISS) Q7KT97 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS)
(24 more)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
6 E1JJR2 (/IDA) P48180 (/IDA) Q7KT97 (/IDA) Q86MN7 (/IDA) Q8T7V5 (/IDA) Q9VWI9 (/IDA)
Acetylcholine receptor activity GO:0015464
Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 O16926 (/ISS) P91197 (/ISS)
Acetylcholine binding GO:0042166
Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
2 Q7KT97 (/IDA) Q8T7V5 (/IDA)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
1 Q9U298 (/IMP)
Showing 1 to 5 of 5 entries

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 E1JJR2 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA)
(23 more)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Response to insecticide GO:0017085
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
5 E1JJR2 (/IMP) O16926 (/IMP) P91197 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 E1JJR2 (/IEP) Q86MN7 (/IEP) Q9VWI9 (/IEP)
Jump response GO:0007630
The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Action potential GO:0001508
A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
1 Q9U298 (/IMP)
Showing 1 to 10 of 31 entries

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
34 E1JJR2 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) Q60S81 (/ISS) Q7KT97 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS)
(24 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
33 E1JJR2 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) Q7KT97 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI)
(23 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
30 M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF8 (/IDA)
(20 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
30 M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF8 (/IDA)
(20 more)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 O16926 (/IC) P91197 (/IC)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9U298 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q60S81 (/ISS)
Showing 1 to 10 of 13 entries
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