The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Nicotinic acetylcholine receptor subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
34 E1JJR2 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) Q60S81 (/ISS) Q7KT97 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS)
(24 more)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
6 E1JJR2 (/IDA) P48180 (/IDA) Q7KT97 (/IDA) Q86MN7 (/IDA) Q8T7V5 (/IDA) Q9VWI9 (/IDA)
Acetylcholine receptor activity GO:0015464
Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 O16926 (/ISS) P91197 (/ISS)
Acetylcholine binding GO:0042166
Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
2 Q7KT97 (/IDA) Q8T7V5 (/IDA)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
1 Q9U298 (/IMP)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 E1JJR2 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA)
(23 more)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Response to insecticide GO:0017085
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
28 M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) M9PFD8 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF7 (/IMP) Q7KTF8 (/IMP) Q7KTF8 (/IMP)
(18 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
5 E1JJR2 (/IMP) O16926 (/IMP) P91197 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 E1JJR2 (/IEP) Q86MN7 (/IEP) Q9VWI9 (/IEP)
Jump response GO:0007630
The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
3 E1JJR2 (/IMP) Q86MN7 (/IMP) Q9VWI9 (/IMP)
Action potential GO:0001508
A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
1 Q9U298 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
1 Q9U298 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
1 Q60S81 (/ISS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9U298 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9U298 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q60S81 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9U298 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9U298 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 Q9U298 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 P48180 (/IDA)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q9U298 (/IMP)
Pharyngeal pumping GO:0043050
The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.
1 Q9U298 (/IMP)
Pharyngeal pumping GO:0043050
The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.
1 Q60S81 (/ISS)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 Q9U298 (/IGI)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 Q9U298 (/IMP)
Multicellular organismal reproductive process GO:0048609
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
1 Q9U298 (/IMP)
Multicellular organismal reproductive process GO:0048609
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
1 Q60S81 (/ISS)
Regulation of brood size GO:0060378
Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.
1 Q9U298 (/IGI)
Regulation of brood size GO:0060378
Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.
1 Q9U298 (/IMP)
Positive regulation of nematode larval development GO:0061063
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q9U298 (/IGI)
Positive regulation of nematode larval development GO:0061063
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q9U298 (/IMP)
Positive regulation of eating behavior GO:1904000
Any process that activates or increases the frequency, rate or extent of eating behavior.
1 Q9U298 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
34 E1JJR2 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) M9PFD8 (/ISS) Q60S81 (/ISS) Q7KT97 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS) Q7KTF7 (/ISS)
(24 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
33 E1JJR2 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) M9PFD8 (/IPI) Q7KT97 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI) Q7KTF7 (/IPI)
(23 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
30 M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF8 (/IDA)
(20 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
30 M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) M9PFD8 (/IDA) Q7KT97 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF7 (/IDA) Q7KTF8 (/IDA)
(20 more)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
3 E1JJR2 (/IDA) Q86MN7 (/IDA) Q9VWI9 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 O16926 (/IC) P91197 (/IC)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9U298 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q60S81 (/ISS)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
1 Q9U298 (/IMP)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 Q9U298 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P48180 (/IDA)
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