The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Acid-sensing ion channels like domains
".
FunFam 4: Degenerin unc-8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
2 | P24612 (/IDA) P34886 (/IDA) |
|
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
|
1 | Q09274 (/IDA) |
|
Cation channel activity GO:0005261
Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
|
1 | Q21974 (/ISS) |
|
Acid-sensing ion channel activity GO:0044736
Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex.
|
1 | O01635 (/ISS) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
|
2 | P24612 (/IGI) P34886 (/IGI) |
|
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
|
2 | P24612 (/IMP) P34886 (/IMP) |
|
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
2 | P24612 (/IMP) P34886 (/IMP) |
|
Detection of mechanical stimulus involved in sensory perception of touch GO:0050976
The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.
|
2 | P24612 (/IGI) P34886 (/IGI) |
|
Positive regulation of detection of mechanical stimulus involved in sensory perception of touch GO:1905789
Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch.
|
2 | P24612 (/IGI) P34886 (/IGI) |
|
Positive regulation of mechanosensory behavior GO:1905792
Any process that activates or increases the frequency, rate or extent of mechanosensory behavior.
|
2 | P24612 (/IGI) P34886 (/IGI) |
|
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q21974 (/ISS) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q09274 (/IDA) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | Q09274 (/IMP) |
|
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
|
1 | P24585 (/IGI) |
|
Magnesium ion transport GO:0015693
The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q09274 (/IDA) |
|
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | O01635 (/ISS) |
|
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
|
1 | Q21974 (/IMP) |
|
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
|
1 | Q21974 (/ISS) |
|
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | P24585 (/IGI) |
|
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | P24585 (/IMP) |
|
Detection of mechanical stimulus involved in sensory perception of touch GO:0050976
The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.
|
1 | P24612 (/IMP) |
|
Negative regulation of turning behavior involved in mating GO:0061096
Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.
|
1 | P24612 (/IMP) |
|
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
|
1 | O01635 (/ISS) |
|
Cellular response to pH GO:0071467
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
|
1 | O01635 (/ISS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q21974 (/IC) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P24612 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | O01635 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q09274 (/IC) |
|
Neuron projection membrane GO:0032589
The portion of the plasma membrane surrounding a neuron projection.
|
1 | P24612 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q21974 (/IDA) |
