The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: NPC intracellular cholesterol transporter 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
30 O97763 (/ISS) O97763 (/ISS) O97763 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS)
(20 more)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
15 O97763 (/IDA) O97763 (/IDA) O97763 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI)
(3 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
12 P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI) P61916 (/IPI)
(2 more)
Cholesterol transfer activity GO:0120020
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Sterol binding GO:0032934
Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
6 Q8IGP0 (/ISS) Q9VA41 (/ISS) Q9VA42 (/ISS) Q9VH31 (/ISS) Q9VH32 (/ISS) Q9VQ62 (/ISS)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
2 Q9VA41 (/IDA) Q9VQ62 (/IDA)
Lipid antigen binding GO:0030882
Interacting selectively and non-covalently with a lipid antigen.
2 Q9VA41 (/IDA) Q9VQ62 (/IDA)
Peptidoglycan binding GO:0042834
Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
2 Q9VA41 (/IDA) Q9VQ62 (/IDA)
Lipoteichoic acid binding GO:0070891
Interacting selectively and non-covalently with lipoteichoic acid.
2 Q9VA41 (/IDA) Q9VQ62 (/IDA)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 Q9Z0J0 (/IMP)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 Q9Z0J0 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q9Z0J0 (/ISO)
Cholesterol transfer activity GO:0120020
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
1 Q9Z0J0 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
30 O97763 (/ISS) O97763 (/ISS) O97763 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS)
(20 more)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
29 O97763 (/ISS) O97763 (/ISS) O97763 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS)
(19 more)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
28 O97763 (/ISS) O97763 (/ISS) O97763 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS) P61917 (/ISS)
(18 more)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
13 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(3 more)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
13 P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP)
(3 more)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
12 P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP) P61916 (/IEP)
(2 more)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Regulation of isoprenoid metabolic process GO:0019747
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Intracellular sterol transport GO:0032366
The directed movement of sterols within cells.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
12 P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI) P61916 (/IGI)
(2 more)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
12 P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP)
(2 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Glycolipid transport GO:0046836
The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
5 Q8IGP0 (/ISS) Q9VA41 (/ISS) Q9VA42 (/ISS) Q9VH31 (/ISS) Q9VH32 (/ISS)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
2 Q8IGP0 (/IEP) Q9VA42 (/IEP)
Synaptic target recognition GO:0008039
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
1 Q9VQ62 (/IMP)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q9VQ62 (/IMP)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z0J0 (/IMP)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z0J0 (/ISO)
Intracellular sterol transport GO:0032366
The directed movement of sterols within cells.
1 Q9Z0J0 (/ISO)
Intracellular sterol transport GO:0032366
The directed movement of sterols within cells.
1 Q9Z0J0 (/ISS)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
1 Q9Z0J0 (/ISO)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q9Z0J0 (/IMP)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q9Z0J0 (/ISO)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q9Z0J0 (/ISO)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q9Z0J0 (/ISS)
Ecdysteroid biosynthetic process GO:0045456
The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.
1 Q9VQ62 (/IGI)
Sterol homeostasis GO:0055092
Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.
1 Q9VQ62 (/IMP)
Peptidoglycan recognition protein signaling pathway GO:0061057
A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
1 Q9VQ62 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
18 A1EA99 (/IDA) O97763 (/IDA) O97763 (/IDA) O97763 (/IDA) P61917 (/IDA) P61917 (/IDA) P61917 (/IDA) P61917 (/IDA) P61917 (/IDA) P61917 (/IDA)
(8 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP) P61916 (/IMP)
(2 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
12 P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA) P61916 (/IDA)
(2 more)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
12 P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS) P61916 (/TAS)
(2 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
12 P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA) P61916 (/HDA)
(2 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q8IGP0 (/HDA) Q9VA41 (/HDA) Q9VA42 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9Z0J0 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9Z0J0 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q9Z0J0 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q9Z0J0 (/ISS)
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