The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 76: Protocadherin alpha 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
6 Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O88689 (/IPI) Q9UN74 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 O88689 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O88689 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
12 Q6ZQD4 (/TAS) Q91Y16 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5H6 (/TAS) Q9Y5H7 (/TAS) Q9Y5H8 (/TAS) Q9Y5H9 (/TAS) Q9Y5I1 (/TAS)
(2 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
10 Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5H6 (/TAS) Q9Y5H7 (/TAS) Q9Y5H8 (/TAS) Q9Y5H9 (/TAS) Q9Y5I1 (/TAS) Q9Y5I2 (/TAS) Q9Y5I3 (/TAS)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
3 I6LBW4 (/NAS) Q767I8 (/NAS) Q767I8 (/NAS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 Q5DRE5 (/ISS) Q9UN72 (/ISS)
Cell-cell recognition GO:0009988
Cell recognition between cells. May involve the formation of specialized cell junctions.
2 Q5DRE5 (/ISS) Q9UN72 (/ISS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 O88689 (/IC)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q767I9 (/NAS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
15 A0A0A6YY44 (/IDA) B9EKB6 (/IDA) O88192 (/IDA) O88193 (/IDA) O88689 (/IDA) O88690 (/IDA) Q641K6 (/IDA) Q6ZQD4 (/IDA) Q91Y14 (/IDA) Q91Y15 (/IDA)
(5 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
10 Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5H6 (/TAS) Q9Y5H7 (/TAS) Q9Y5H8 (/TAS) Q9Y5H9 (/TAS) Q9Y5I1 (/TAS) Q9Y5I2 (/TAS) Q9Y5I3 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
6 B9EJ92 (/IDA) O88689 (/IDA) Q05C01 (/IDA) Q641K6 (/IDA) Q91Y17 (/IDA) Q91Y21 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 B9EJ92 (/IDA) Q05C01 (/IDA) Q91Y17 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q5DRE5 (/ISS) Q9UN72 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O88689 (/IDA)
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