The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Protocadherin alpha 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 A0A0A6YW27 (/IPI) O88689 (/IPI) Q6NXW8 (/IPI) Q7TQF1 (/IPI) Q80TE2 (/IPI) Q8BNI7 (/IPI) Q91XX6 (/IPI) Q91XX7 (/IPI) Q91XX8 (/IPI) Q91XY5 (/IPI)
(6 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 Q5DRC6 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN66 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS) Q9Y5E3 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
10 Q5DRC6 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN66 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS) Q9Y5E3 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 O88689 (/IDA) Q91XZ2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O88689 (/IDA) Q91XZ2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9Y5G4 (/HDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
22 Q6ZQD4 (/TAS) Q91Y16 (/TAS) Q9H158 (/TAS) Q9UN71 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS)
(12 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
19 Q9H158 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS) Q9Y5E8 (/TAS) Q9Y5F1 (/TAS)
(9 more)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
15 Q91Y03 (/NAS) Q9HAB4 (/NAS) Q9NRJ7 (/NAS) Q9UN67 (/NAS) Q9UN70 (/NAS) Q9UN71 (/NAS) Q9Y5E1 (/NAS) Q9Y5E3 (/NAS) Q9Y5E4 (/NAS) Q9Y5E5 (/NAS)
(5 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
13 Q91Y03 (/TAS) Q9HAB4 (/TAS) Q9NRJ7 (/TAS) Q9UN67 (/TAS) Q9Y5E1 (/TAS) Q9Y5E3 (/TAS) Q9Y5E4 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS)
(3 more)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
13 Q91Y03 (/TAS) Q9HAB4 (/TAS) Q9NRJ7 (/TAS) Q9UN67 (/TAS) Q9Y5E1 (/TAS) Q9Y5E3 (/TAS) Q9Y5E4 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS)
(3 more)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
8 E9PX28 (/IDA) E9PXQ7 (/IDA) Q6P0A6 (/IDA) Q80TE2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA) Q925I8 (/IDA) Q9Z1B1 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
6 E9PX28 (/IDA) E9PXQ7 (/IDA) Q6P0A6 (/IDA) Q80TE2 (/IDA) Q925I8 (/IDA) Q9Z1B1 (/IDA)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
5 Q3UTF9 (/IGI) Q8K4A2 (/IGI) Q91XW9 (/IGI) Q91XX0 (/IGI) Q91XX1 (/IGI)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
4 Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q9UN72 (/ISS) Q9Y5E3 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 I6LBW8 (/NAS) I6LBX8 (/NAS) Q767I4 (/NAS) Q767I9 (/NAS)
Cell-cell recognition GO:0009988
Cell recognition between cells. May involve the formation of specialized cell junctions.
4 Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q9UN72 (/ISS) Q9Y5E3 (/ISS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
3 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q805F0 (/IMP)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
3 Q6NXW8 (/ISS) Q91XY7 (/ISS) Q9Z1B0 (/ISS)
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
3 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q805F0 (/IMP)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
3 I6LBW4 (/NAS) Q767I8 (/NAS) Q767I8 (/NAS)
Paraxial mesoderm development GO:0048339
The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.
3 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q805F0 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 O88689 (/IC) Q91XZ2 (/IC)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 F1LRA0 (/IEP) I6LBX6 (/IEP)
Cell-cell recognition GO:0009988
Cell recognition between cells. May involve the formation of specialized cell junctions.
2 Q91XZ4 (/IDA) Q91Y13 (/IDA)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q91XX1 (/TAS)
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
1 Q91XY5 (/IMP)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 Q91XX1 (/TAS)
Lipid tube assembly involved in organelle fusion GO:0060989
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse.
1 Q91XY5 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
56 A0A0A6YW27 (/IDA) A0A0A6YXT1 (/IDA) A0A0A6YY44 (/IDA) A0A0A6YY55 (/IDA) B9EKB6 (/IDA) O88192 (/IDA) O88193 (/IDA) O88689 (/IDA) O88690 (/IDA) Q3UTF9 (/IDA)
(46 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
22 Q767H8 (/TAS) Q767I5 (/TAS) Q91XX1 (/TAS) Q9H158 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS)
(12 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
13 Q91Y03 (/NAS) Q9HAB4 (/NAS) Q9NRJ7 (/NAS) Q9UN67 (/NAS) Q9Y5E1 (/NAS) Q9Y5E3 (/NAS) Q9Y5E4 (/NAS) Q9Y5E5 (/NAS) Q9Y5E6 (/NAS) Q9Y5E7 (/NAS)
(3 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 A0PJT6 (/ISS) E9PX28 (/ISS) E9PXQ7 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q6P0A6 (/ISS) Q80TE2 (/ISS) Q91Y07 (/ISS) Q925I8 (/ISS) Q9UN72 (/ISS)
(2 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
6 B9EJ92 (/IDA) O88689 (/IDA) Q05C01 (/IDA) Q641K6 (/IDA) Q91Y17 (/IDA) Q91Y21 (/IDA)
Photoreceptor connecting cilium GO:0032391
The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
6 Q14BM8 (/IDA) Q8C8Z3 (/IDA) Q8CB45 (/IDA) Q91XZ8 (/IDA) Q91Y03 (/IDA) Q925L0 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
5 A0PJT6 (/IDA) Q6NXW8 (/IDA) Q91XY7 (/IDA) Q91Y07 (/IDA) Q9Z1B0 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 O88689 (/IDA) Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 B9EJ92 (/IDA) Q05C01 (/IDA) Q91Y17 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q6NXW8 (/ISS) Q91XY7 (/ISS) Q9Z1B0 (/ISS)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
3 Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
3 Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q767H8 (/TAS) Q767I5 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q767H8 (/TAS) Q767I5 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q91XZ4 (/IDA) Q91Y13 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9UN70 (/NAS) Q9UN71 (/NAS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 Q7TQF1 (/IDA) Q91XX8 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q91XX1 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9Y5G0 (/HDA)
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