The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 500: Cadherin-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q90275 (/ISS) Q90275 (/ISS)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
2 Q90275 (/IMP) Q90275 (/IMP)
Cartilage condensation GO:0001502
The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
2 Q90275 (/IMP) Q90275 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
2 Q90275 (/IGI) Q90275 (/IGI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
2 Q90275 (/IMP) Q90275 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 Q90275 (/IMP) Q90275 (/IMP)
Neuron cell-cell adhesion GO:0007158
The attachment of a neuron to another cell via adhesion molecules.
2 Q90275 (/IMP) Q90275 (/IMP)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
2 Q90275 (/IMP) Q90275 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q90275 (/IMP) Q90275 (/IMP)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
2 Q90275 (/IMP) Q90275 (/IMP)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
2 Q90275 (/IEP) Q90275 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q90275 (/IMP) Q90275 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
2 Q90275 (/IMP) Q90275 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 Q90275 (/IMP) Q90275 (/IMP)
Glial cell differentiation GO:0010001
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
2 Q90275 (/ISS) Q90275 (/ISS)
Cardioblast differentiation GO:0010002
The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
2 Q90275 (/IMP) Q90275 (/IMP)
Spinal cord patterning GO:0021511
The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.
2 Q90275 (/IMP) Q90275 (/IMP)
Cell migration in hindbrain GO:0021535
The orderly movement of a cell that will reside in the hindbrain.
2 Q90275 (/IMP) Q90275 (/IMP)
Hindbrain structural organization GO:0021577
The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2 Q90275 (/IMP) Q90275 (/IMP)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
2 Q90275 (/IMP) Q90275 (/IMP)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
2 Q90275 (/IMP) Q90275 (/IMP)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
2 Q90275 (/IMP) Q90275 (/IMP)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
2 Q90275 (/IMP) Q90275 (/IMP)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2 Q90275 (/IMP) Q90275 (/IMP)
Embryonic pectoral fin morphogenesis GO:0035118
The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
2 Q90275 (/IMP) Q90275 (/IMP)
Dorsal fin morphogenesis GO:0035142
The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.
2 Q90275 (/IMP) Q90275 (/IMP)
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
2 Q90275 (/IGI) Q90275 (/IGI)
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
2 Q90275 (/IMP) Q90275 (/IMP)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
2 Q90275 (/IEP) Q90275 (/IEP)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
2 Q90275 (/IMP) Q90275 (/IMP)
Regulation of eye photoreceptor cell development GO:0042478
Any process that modulates the frequency, rate or extent of eye photoreceptor development.
2 Q90275 (/IMP) Q90275 (/IMP)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
2 Q90275 (/ISS) Q90275 (/ISS)
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
2 Q90275 (/IMP) Q90275 (/IMP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
2 Q90275 (/IMP) Q90275 (/IMP)
Axial mesoderm structural organization GO:0048331
The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure.
2 Q90275 (/IMP) Q90275 (/IMP)
Mesoderm morphogenesis GO:0048332
The process in which the anatomical structures of the mesoderm are generated and organized.
2 Q90275 (/IMP) Q90275 (/IMP)
Generation of neurons GO:0048699
The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
2 Q90275 (/IMP) Q90275 (/IMP)
Semicircular canal morphogenesis GO:0048752
The process in which the anatomical structures of the semicircular canals are generated and organized.
2 Q90275 (/IMP) Q90275 (/IMP)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
2 Q90275 (/IGI) Q90275 (/IGI)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
2 Q90275 (/IMP) Q90275 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
2 Q90275 (/IMP) Q90275 (/IMP)
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
2 Q90275 (/IMP) Q90275 (/IMP)
Auditory receptor cell stereocilium organization GO:0060088
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
2 Q90275 (/IMP) Q90275 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
2 Q90275 (/IMP) Q90275 (/IMP)
Pigment cell development GO:0070285
The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.
2 Q90275 (/IGI) Q90275 (/IGI)
Sensory epithelium regeneration GO:0070654
The regrowth of a sensory epithelium following its loss or destruction.
2 Q90275 (/IMP) Q90275 (/IMP)
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
2 Q90275 (/IMP) Q90275 (/IMP)
Cell migration involved in somitogenic axis elongation GO:0090248
The orderly movement of a presomitic mesoderm cell that contributes to somitogenic axis elongation.
2 Q90275 (/IMP) Q90275 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 Q90275 (/ISS) Q90275 (/ISS)
Motor neuron migration GO:0097475
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
2 Q90275 (/IMP) Q90275 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 Q90275 (/ISS) Q90275 (/ISS)
Cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742
The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
2 Q90275 (/IMP) Q90275 (/IMP)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
2 Q90275 (/IMP) Q90275 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q90275 (/IDA) Q90275 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q90275 (/ISS) Q90275 (/ISS)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2 Q90275 (/ISS) Q90275 (/ISS)
Catenin complex GO:0016342
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
2 Q90275 (/IDA) Q90275 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
2 Q90275 (/IDA) Q90275 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q90275 (/IDA) Q90275 (/IDA)
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