The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 261: Cadherin-related family member 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q8VHF2 (/ISS) Q9HBB8 (/ISS)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9JIK1 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8VHF2 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9HBB8 (/IPI)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
1 Q9HBB8 (/IPI)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
1 Q8VHF2 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q9HBB8 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q8VHF2 (/ISO)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 Q8VHF2 (/ISS) Q9HBB8 (/ISS)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q9JIK1 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q9JIK1 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q8VHF2 (/ISO)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 Q9HBB8 (/IMP)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 Q8VHF2 (/ISO)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 Q9HBB8 (/IMP)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 Q8VHF2 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
2 Q8VHF2 (/ISS) Q9JIK1 (/ISS)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q58EZ6 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q9JIK1 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q8VHF2 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9JIK1 (/NAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q9HBB8 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q8VHF2 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q9HBB8 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q8VHF2 (/ISO)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 Q9HBB8 (/IDA)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 Q8VHF2 (/ISO)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q9HBB8 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q8VHF2 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9HBB8 (/HDA)
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