The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 151: Cadherin 17

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proton-dependent oligopeptide secondary active transmembrane transporter activity GO:0005427
Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.
18 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(8 more)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q12864 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q9R100 (/ISO)
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
1 Q12864 (/TAS)
Proton-dependent oligopeptide secondary active transmembrane transporter activity GO:0005427
Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.
1 Q9R100 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9R100 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oligopeptide transport GO:0006857
The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
18 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(8 more)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
18 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(8 more)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
18 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(8 more)
Oligopeptide transmembrane transport GO:0035672
The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
18 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(8 more)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 F1RD80 (/IMP) Q6P3M3 (/IMP) Q803S8 (/IMP) Q90X63 (/IMP)
Germinal center B cell differentiation GO:0002314
The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
1 Q9R100 (/IMP)
Marginal zone B cell differentiation GO:0002315
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
1 Q9R100 (/IMP)
Oligopeptide transport GO:0006857
The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
1 Q9R100 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q12864 (/TAS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q9R100 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q12864 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9R100 (/ISO)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 Q9R100 (/IDA)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
1 Q9R100 (/IMP)
Positive regulation of integrin activation by cell surface receptor linked signal transduction GO:0033626
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands.
1 Q12864 (/IMP)
Positive regulation of integrin activation by cell surface receptor linked signal transduction GO:0033626
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands.
1 Q9R100 (/ISO)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
1 Q12864 (/TAS)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
1 Q9R100 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
17 A0A2J8PLX9 (/ISS) A0A2J8UGD3 (/ISS) A6H7H6 (/ISS) F1RY44 (/ISS) F6PPF8 (/ISS) F7E6P0 (/ISS) F7GJC2 (/ISS) G1QRW3 (/ISS) G1SEK5 (/ISS) G3R9G1 (/ISS)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 E7EN24 (/IDA) Q12864 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P55281 (/IDA) Q12864 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
2 E7EN24 (/IDA) Q12864 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9R100 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9R100 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q12864 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9R100 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9R100 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q9R100 (/ISO)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q9R100 (/ISO)
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