The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
ntegrin, alpha v. Chain A, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Integrin subunit alpha 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 D3ZCG9 (/IPI) D3ZQM3 (/IPI) P26006 (/IPI) P26006 (/IPI) Q62470 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P26006 (/IPI) P26006 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 D3ZCG9 (/IPI) D3ZQM3 (/IPI)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P26006 (/IDA) P26006 (/IDA)
Showing 1 to 10 of 18 entries

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
2 P26006 (/TAS) P26006 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 D3ZCG9 (/IEP) D3ZQM3 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
2 P26006 (/IMP) P26006 (/IMP)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
2 P26006 (/IMP) P26006 (/IMP)
Showing 1 to 10 of 48 entries

There are 35 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA) Q62470 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
4 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P26006 (/TAS) P26006 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P26006 (/HDA) P26006 (/HDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 P26006 (/TAS) P26006 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P26006 (/HDA) P26006 (/HDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Showing 1 to 10 of 35 entries
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