The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 56: Protein kinase C epsilon

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P09216 (/IPI) P16054 (/IPI) P23298 (/IPI) P24723 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI)
(1 more)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
8 P16054 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
8 P24723 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI) Q02156 (/IPI)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
7 Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
7 Q02156 (/IMP) Q02156 (/IMP) Q02156 (/IMP) Q02156 (/IMP) Q02156 (/IMP) Q02156 (/IMP) Q02156 (/IMP)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
7 Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Calcium-independent protein kinase C activity GO:0004699
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
2 P16054 (/IDA) Q64617 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P16054 (/ISO) P23298 (/ISO)
Showing 1 to 10 of 27 entries

There are 98 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
9 P16054 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q64617 (/IDA)
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
TRAM-dependent toll-like receptor 4 signaling pathway GO:0035669
Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
7 Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Showing 1 to 10 of 98 entries

There are 32 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P09216 (/IDA) P16054 (/IDA) P23298 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P09216 (/IDA) P23298 (/IDA) P24723 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P16054 (/IDA) P24723 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
9 P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS) Q02156 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P24723 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
7 Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA) Q02156 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS) Q02156 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P16054 (/ISO) P23298 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P16054 (/ISO) P23298 (/ISO)
Showing 1 to 10 of 32 entries
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