The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 81: Myosin-binding protein C, slow type

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O70468 (/IPI) Q00872 (/IPI) Q14324 (/IPI) Q14324 (/IPI) Q14896 (/IPI)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
4 D3YU50 (/TAS) O70468 (/TAS) Q5XKE0 (/TAS) Q6P6L5 (/TAS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
3 Q00872 (/TAS) Q14324 (/TAS) Q14324 (/TAS)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
2 O70468 (/IPI) Q14896 (/IPI)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
1 Q90688 (/IDA)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
1 Q14896 (/ISS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 Q14896 (/IMP)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 O70468 (/ISO)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 Q14896 (/IDA)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 O70468 (/ISO)
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
1 A6QP89 (/IDA)
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
1 Q00872 (/ISS)
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
1 Q14896 (/NAS)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
1 O70468 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q14896 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O70468 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
4 D3YU50 (/IDA) O70468 (/IDA) Q5XKE0 (/IDA) Q6P6L5 (/IDA)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
4 Q00872 (/TAS) Q14324 (/TAS) Q14324 (/TAS) Q14896 (/TAS)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
3 A0A1L1QZU5 (/IMP) E7EZ79 (/IMP) O70468 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
3 A5WWB7 (/IMP) F1Q545 (/IMP) Q5U3B1 (/IMP)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
3 A0A1L1QZU5 (/IMP) E7EZ79 (/IMP) Q14896 (/IMP)
Muscle tissue development GO:0060537
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
3 F1Q699 (/IMP) F1R6I7 (/IMP) Q5BJ14 (/IMP)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 O70468 (/IMP) Q14896 (/IMP)
Cardiac atrium formation GO:0003210
The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
2 A0A1L1QZU5 (/IMP) E7EZ79 (/IMP)
Cardiac ventricle formation GO:0003211
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
2 A0A1L1QZU5 (/IMP) E7EZ79 (/IMP)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 O70468 (/ISO)
Regulation of striated muscle contraction GO:0006942
Any process that modulates the frequency, rate or extent of striated muscle contraction.
1 P56741 (/IEP)
Regulation of striated muscle contraction GO:0006942
Any process that modulates the frequency, rate or extent of striated muscle contraction.
1 Q14896 (/ISS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 O70468 (/IMP)
Myosin filament assembly GO:0031034
The aggregation, arrangement and bonding together of a filament composed of myosin molecules.
1 O70468 (/IMP)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
1 Q90688 (/IDA)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
1 Q14896 (/ISS)
Regulation of muscle filament sliding GO:0032971
Any process that modulates the frequency, rate or extent of muscle filament sliding.
1 Q90688 (/IDA)
Regulation of muscle filament sliding GO:0032971
Any process that modulates the frequency, rate or extent of muscle filament sliding.
1 Q14896 (/ISS)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 O70468 (/IMP)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
1 O70468 (/ISO)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 P56741 (/IEP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 O70468 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 Q14896 (/ISS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
26 A0A087QYK7 (/ISS) A0A091F2Q4 (/ISS) A0A091GNZ0 (/ISS) A0A091IAB2 (/ISS) A0A091JSL5 (/ISS) A0A091JT64 (/ISS) A0A091KXT1 (/ISS) A0A091LBV6 (/ISS) A0A091Q0I0 (/ISS) A0A091TGE7 (/ISS)
(16 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q00872 (/TAS) Q14324 (/TAS) Q14324 (/TAS) Q14896 (/TAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
4 D3YU50 (/TAS) O70468 (/TAS) Q5XKE0 (/TAS) Q6P6L5 (/TAS)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
3 O70468 (/IDA) P16419 (/IDA) Q14896 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 P16419 (/IDA) Q90688 (/IDA)
Striated muscle myosin thick filament GO:0005863
Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.
2 P56741 (/IDA) Q14896 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
2 A6QP89 (/IDA) O70468 (/IDA)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 O70468 (/IDA) Q14896 (/IDA)
Striated muscle myosin thick filament GO:0005863
Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.
1 O70468 (/ISO)
Striated muscle myosin thick filament GO:0005863
Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.
1 Q14896 (/ISS)
C zone GO:0014705
A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin.
1 Q14896 (/NAS)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 Q00872 (/ISS)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 O70468 (/ISO)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
1 O70468 (/ISO)
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 Q14896 (/IDA)
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 O70468 (/ISO)
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