The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 470: SLAM family member 7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q8BHK6 (/IPI) Q96DU3 (/IPI) Q9UIB8 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9NQ25 (/IPI) Q9UIB8 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q18PI6 (/ISO) Q8BHK6 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
4 Q01965 (/ISO) Q01965 (/ISO) Q9ET39 (/ISO) Q9ET39 (/ISO)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
4 Q01965 (/ISO) Q01965 (/ISO) Q9ET39 (/ISO) Q9ET39 (/ISO)
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
3 Q96DU3 (/IDA) Q9HBG7 (/IDA) Q9HBG7 (/IDA)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
3 Q96DU3 (/IDA) Q9HBG7 (/IDA) Q9HBG7 (/IDA)
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
2 Q9ET39 (/IMP) Q9ET39 (/IMP)
Natural killer cell proliferation GO:0001787
The expansion of a natural killer cell population by cell division.
2 Q9ET39 (/IMP) Q9ET39 (/IMP)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 Q9ET39 (/ISO) Q9ET39 (/ISO)
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
2 Q9ET39 (/ISO) Q9ET39 (/ISO)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
2 Q96DU3 (/TAS) Q9NQ25 (/TAS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
1 Q9UIB8 (/TAS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q9NQ25 (/NAS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q9UIB8 (/TAS)
Natural killer cell activation GO:0030101
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q9NQ25 (/NAS)
Regulation of lipopolysaccharide-mediated signaling pathway GO:0031664
Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
1 Q18PI6 (/IDA)
Negative regulation of granulocyte macrophage colony-stimulating factor production GO:0032685
Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
1 Q9UIB8 (/IDA)
Negative regulation of granulocyte macrophage colony-stimulating factor production GO:0032685
Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
1 Q18PI6 (/ISO)
Negative regulation of interleukin-18 production GO:0032701
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.
1 Q9UIB8 (/IDA)
Negative regulation of interleukin-18 production GO:0032701
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.
1 Q18PI6 (/ISO)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q96DU3 (/IMP)
Regulation of natural killer cell activation GO:0032814
Any process that modulates the frequency, rate or extent of natural killer cell activation.
1 Q8BHK6 (/IGI)
Negative regulation of mast cell activation GO:0033004
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.
1 Q9UIB8 (/IDA)
Negative regulation of mast cell activation GO:0033004
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.
1 Q18PI6 (/ISO)
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
1 Q9NQ25 (/NAS)
Regulation of macrophage activation GO:0043030
Any process that modulates the frequency or rate of macrophage activation.
1 Q18PI6 (/IDA)
Negative regulation of mast cell degranulation GO:0043305
Any process that stops, prevents, or reduces the rate of mast cell degranulation.
1 Q9UIB8 (/IDA)
Negative regulation of mast cell degranulation GO:0043305
Any process that stops, prevents, or reduces the rate of mast cell degranulation.
1 Q18PI6 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q18PI6 (/IDA)
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
1 Q96DU3 (/IDA)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 Q9UIB8 (/TAS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q18PI6 (/IDA)
Positive regulation of monocyte chemotactic protein-1 production GO:0071639
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
1 Q18PI6 (/IDA)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 Q18PI6 (/IDA)
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
1 Q18PI6 (/IDA)
Negative regulation of interleukin-10 secretion GO:2001180
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.
1 Q18PI6 (/IDA)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
1 Q9UIB8 (/IDA)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
1 Q18PI6 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q8BHK6 (/IDA) Q96DU3 (/IDA) Q9HBG7 (/IDA) Q9HBG7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q01965 (/ISO) Q01965 (/ISO) Q9ET39 (/ISO) Q9ET39 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q96DU3 (/TAS) Q9NQ25 (/TAS) Q9UIB8 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9ET39 (/ISS) Q9ET39 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q01965 (/IDA) Q01965 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 B4DW98 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q8BHK6 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9UIB8 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q8BHK6 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q96DU3 (/HDA)
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