The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2969: T-cell surface glycoprotein CD4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P06332 (/ISO) P06332 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P06332 (/IPI) P06332 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P06332 (/ISO) P06332 (/ISO)
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
2 P06332 (/ISO) P06332 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P06332 (/ISO) P06332 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P06332 (/ISO) P06332 (/ISO)
Interleukin-16 binding GO:0042011
Interacting selectively and non-covalently with interleukin-16.
2 P06332 (/ISO) P06332 (/ISO)
Interleukin-16 receptor activity GO:0042012
Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P06332 (/ISO) P06332 (/ISO)
MHC class II protein binding GO:0042289
Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2 P06332 (/ISO) P06332 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P06332 (/ISO) P06332 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P06332 (/ISO) P06332 (/ISO)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
2 P06332 (/ISO) P06332 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P05540 (/IPI)
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
1 P05540 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P05540 (/IPI)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
1 P05540 (/IDA)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
3 P05540 (/ISS) P06332 (/ISS) P06332 (/ISS)
T cell selection GO:0045058
The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
3 P05540 (/ISS) P06332 (/ISS) P06332 (/ISS)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P06332 (/IGI) P06332 (/IGI)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P06332 (/IMP) P06332 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 P06332 (/ISO) P06332 (/ISO)
Induction by virus of host cell-cell fusion GO:0006948
The process of syncytia-forming cell-cell fusion, caused by a virus.
2 P06332 (/ISO) P06332 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P06332 (/IDA) P06332 (/IDA)
Positive regulation of calcium ion transport into cytosol GO:0010524
Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
2 P06332 (/ISO) P06332 (/ISO)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
2 P06332 (/ISO) P06332 (/ISO)
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2 P06332 (/ISO) P06332 (/ISO)
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 P06332 (/ISO) P06332 (/ISO)
Helper T cell enhancement of adaptive immune response GO:0035397
Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.
2 P06332 (/IMP) P06332 (/IMP)
Interleukin-15-mediated signaling pathway GO:0035723
A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P06332 (/ISO) P06332 (/ISO)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 P06332 (/ISO) P06332 (/ISO)
T cell selection GO:0045058
The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of monocyte differentiation GO:0045657
Any process that activates or increases the frequency, rate or extent of monocyte differentiation.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of viral entry into host cell GO:0046598
Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P06332 (/IDA) P06332 (/IDA)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 P06332 (/IMP) P06332 (/IMP)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
2 P06332 (/IDA) P06332 (/IDA)
Regulation of T cell activation GO:0050863
Any process that modulates the frequency, rate or extent of T cell activation.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
2 P06332 (/IDA) P06332 (/IDA)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P06332 (/ISO) P06332 (/ISO)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
2 P06332 (/ISO) P06332 (/ISO)
Positive regulation of calcium ion transport into cytosol GO:0010524
Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
1 P05540 (/IDA)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P05540 (/IEP)
Response to vitamin D GO:0033280
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
1 P05540 (/IEP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P05540 (/IMP)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
1 P05540 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P05540 (/IDA) P06332 (/IDA) P06332 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 P05540 (/IDA) P06332 (/IDA) P06332 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 P06332 (/IDA) P06332 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P06332 (/IDA) P06332 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P06332 (/ISO) P06332 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P06332 (/ISO) P06332 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 P06332 (/ISO) P06332 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P06332 (/IDA) P06332 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P06332 (/IDA) P06332 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P06332 (/ISO) P06332 (/ISO)
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