The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Down syndrome cell adhesion molecule b

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
154 A0A0B4K6Q9 (/IPI) A0A0B4K6R4 (/IPI) A0A0B4K6R4 (/IPI) A0A0B4K6R8 (/IPI) A0A0B4K6R8 (/IPI) A0A0B4K6S2 (/IPI) A0A0B4K6S2 (/IPI) A0A0B4K6Y9 (/IPI) A0A0B4K6Z3 (/IPI) A0A0B4K6Z3 (/IPI)
(144 more)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
145 A0A0B4K6Q9 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6Y9 (/IDA) A0A0B4K6Z3 (/IDA) A0A0B4K6Z3 (/IDA)
(135 more)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
145 A0A0B4K6Q9 (/IPI) A0A0B4K6R4 (/IPI) A0A0B4K6R4 (/IPI) A0A0B4K6R8 (/IPI) A0A0B4K6R8 (/IPI) A0A0B4K6S2 (/IPI) A0A0B4K6S2 (/IPI) A0A0B4K6Y9 (/IPI) A0A0B4K6Z3 (/IPI) A0A0B4K6Z3 (/IPI)
(135 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
12 B7Z0D9 (/ISS) B7Z0D9 (/ISS) B7Z0D9 (/ISS) B7Z0D9 (/ISS) M9PHS6 (/ISS) M9PHS6 (/ISS) M9PHS6 (/ISS) M9PHS6 (/ISS) Q0E8G9 (/ISS) Q0E8G9 (/ISS)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) Q9ERC8 (/IPI) Q9ERC8 (/IPI) Q9ERC8 (/IPI)
Netrin receptor binding GO:1990890
Interacting selectively and non-covalently with a netrin receptor.
9 O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) O60469 (/IPI) Q9ERC8 (/IPI) Q9ERC8 (/IPI) Q9ERC8 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q8TD84 (/IDA) Q8TD84 (/IDA) Q8TD84 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q4VA61 (/ISO) Q4VA61 (/ISO) Q4VA61 (/ISO)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
3 Q9ERC8 (/IPI) Q9ERC8 (/IPI) Q9ERC8 (/IPI)
Showing 1 to 10 of 11 entries

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Dendrite self-avoidance GO:0070593
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
151 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(141 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
148 A0A0B4K6Q9 (/IGI) A0A0B4K6R4 (/IGI) A0A0B4K6R4 (/IGI) A0A0B4K6R8 (/IGI) A0A0B4K6R8 (/IGI) A0A0B4K6S2 (/IGI) A0A0B4K6S2 (/IGI) A0A0B4K6Y9 (/IGI) A0A0B4K6Z3 (/IGI) A0A0B4K6Z3 (/IGI)
(138 more)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
145 A0A0B4K6Q9 (/TAS) A0A0B4K6R4 (/TAS) A0A0B4K6R4 (/TAS) A0A0B4K6R8 (/TAS) A0A0B4K6R8 (/TAS) A0A0B4K6S2 (/TAS) A0A0B4K6S2 (/TAS) A0A0B4K6Y9 (/TAS) A0A0B4K6Z3 (/TAS) A0A0B4K6Z3 (/TAS)
(135 more)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
145 A0A0B4K6Q9 (/IGI) A0A0B4K6R4 (/IGI) A0A0B4K6R4 (/IGI) A0A0B4K6R8 (/IGI) A0A0B4K6R8 (/IGI) A0A0B4K6S2 (/IGI) A0A0B4K6S2 (/IGI) A0A0B4K6Y9 (/IGI) A0A0B4K6Z3 (/IGI) A0A0B4K6Z3 (/IGI)
(135 more)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Central nervous system morphogenesis GO:0021551
The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
145 A0A0B4K6Q9 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R4 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6R8 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6S2 (/IMP) A0A0B4K6Y9 (/IMP) A0A0B4K6Z3 (/IMP) A0A0B4K6Z3 (/IMP)
(135 more)
Showing 1 to 10 of 60 entries

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
166 A0A0B4K6Q9 (/ISM) A0A0B4K6R4 (/ISM) A0A0B4K6R4 (/ISM) A0A0B4K6R8 (/ISM) A0A0B4K6R8 (/ISM) A0A0B4K6S2 (/ISM) A0A0B4K6S2 (/ISM) A0A0B4K6Y9 (/ISM) A0A0B4K6Z3 (/ISM) A0A0B4K6Z3 (/ISM)
(156 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
148 A0A0B4K6Q9 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6Y9 (/IDA) A0A0B4K6Z3 (/IDA) A0A0B4K6Z3 (/IDA)
(138 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
148 A0A0B4K6Q9 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6Y9 (/IDA) A0A0B4K6Z3 (/IDA) A0A0B4K6Z3 (/IDA)
(138 more)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
148 A0A0B4K6Q9 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6Y9 (/IDA) A0A0B4K6Z3 (/IDA) A0A0B4K6Z3 (/IDA)
(138 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
145 A0A0B4K6Q9 (/ISS) A0A0B4K6R4 (/ISS) A0A0B4K6R4 (/ISS) A0A0B4K6R8 (/ISS) A0A0B4K6R8 (/ISS) A0A0B4K6S2 (/ISS) A0A0B4K6S2 (/ISS) A0A0B4K6Y9 (/ISS) A0A0B4K6Z3 (/ISS) A0A0B4K6Z3 (/ISS)
(135 more)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
145 A0A0B4K6Q9 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R4 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6R8 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6S2 (/IDA) A0A0B4K6Y9 (/IDA) A0A0B4K6Z3 (/IDA) A0A0B4K6Z3 (/IDA)
(135 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 O60469 (/TAS) O60469 (/TAS) O60469 (/TAS) O60469 (/TAS) O60469 (/TAS) O60469 (/TAS) Q8TD84 (/TAS) Q8TD84 (/TAS) Q8TD84 (/TAS) Q9ERC8 (/TAS)
(2 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 A0A2R8Q6S7 (/IDA) A0A2R8Q6S7 (/IDA) A0A2R8Q6S7 (/IDA) A0A2R8QL08 (/IDA) A0A2R8QL08 (/IDA) A0A2R8QL08 (/IDA) F1QGY4 (/IDA) F1QGY4 (/IDA) F1QGY4 (/IDA) Q53CM6 (/IDA)
(2 more)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
12 O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) Q8VHZ8 (/ISS) Q8VHZ8 (/ISS) Q8VHZ8 (/ISS) Q9ERC8 (/ISS)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) O60469 (/ISS) Q8VHZ8 (/ISS) Q8VHZ8 (/ISS) Q8VHZ8 (/ISS)
Showing 1 to 10 of 23 entries
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