The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 142: V-set domain-containing T-cell activation inhibito...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | A7XUX6 (/IDA) Q7TSP5 (/IDA) |
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q90712 (/IDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q7TSP5 (/IGI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9UM44 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | A5HUK9 (/IDA) |
|
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
|
1 | A7XUX6 (/IDA) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
2 | A7XUX6 (/IDA) Q7TSP5 (/IDA) |
|
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
|
2 | P78410 (/IMP) Q7TSP5 (/IMP) |
|
Response to protozoan GO:0001562
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
|
1 | Q7TSP5 (/IMP) |
|
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
|
1 | Q9UM44 (/IDA) |
|
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
|
1 | P78410 (/IMP) |
|
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
|
1 | Q9UM44 (/IDA) |
|
Positive regulation of T cell differentiation in thymus GO:0033089
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
|
1 | A7TZE6 (/IMP) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | Q7TSP5 (/IMP) |
|
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
1 | Q9UM44 (/IDA) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q7Z7D3 (/IMP) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q7TSP5 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q7Z7D3 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q7TSP5 (/ISO) |
|
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
|
1 | A7TZE6 (/IDA) |
|
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
|
1 | A7TZE6 (/IMP) |
|
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
|
1 | A7TZE6 (/IDA) |
|
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | A0A0G2JY27 (/TAS) |
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
1 | Q7Z7D3 (/IMP) |
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
1 | Q7TSP5 (/ISO) |
|
Interleukin-4 secretion GO:0072602
The regulated release of interleukin-4 from a cell.
|
1 | Q7TSP5 (/IMP) |
|
Positive regulation of interleukin-2 secretion GO:1900042
Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion.
|
1 | Q7TSP5 (/IMP) |
|
Regulation of actin binding GO:1904616
Any process that modulates the frequency, rate or extent of actin binding.
|
1 | Q90712 (/IDA) |
|
Negative regulation of actin-dependent ATPase activity GO:1904622
Any process that stops, prevents or reduces the frequency, rate or extent of actin-dependent ATPase activity.
|
1 | Q90712 (/IDA) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | B2ZEZ5 (/IDA) P78410 (/IDA) Q8CG82 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | Q7TSP5 (/IDA) Q7Z7D3 (/IDA) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | Q90712 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P78410 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q90712 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q7TSP5 (/ISO) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | A5HUK9 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P78410 (/HDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | A7TZE6 (/ISM) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q90712 (/IDA) |
|
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
|
1 | Q90712 (/IDA) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
1 | A7TZE6 (/IDA) |
