The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Substrate Binding Domain Of DNAk; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: Heat shock protein 105 kDa isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P48722 (/IPI) Q61699 (/IPI) Q92598 (/IPI) Q92598 (/IPI) Q92598 (/IPI) Q92598 (/IPI) Q92598 (/IPI)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
5 Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
5 Q0IIM3 (/ISS) Q5R606 (/ISS) Q60446 (/ISS) Q61699 (/ISS) Q66HA8 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 O95757 (/ISS) O95757 (/ISS) P48722 (/ISS)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
1 Q61699 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P48722 (/ISO)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 Q61699 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
8 O95757 (/TAS) O95757 (/TAS) Q61699 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Positive regulation of MHC class I biosynthetic process GO:0045345
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.
6 Q61699 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
6 Q61699 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
5 Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
5 Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
3 O95757 (/ISS) O95757 (/ISS) P48722 (/ISS)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
3 O95757 (/ISS) O95757 (/ISS) P48722 (/ISS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 P48722 (/ISO)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
1 P48722 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q61699 (/TAS)
Chaperone cofactor-dependent protein refolding GO:0051085
The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
1 Q61699 (/IDA)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q61699 (/NAS)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
18 A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A0A0MSM0 (/IDA)
(8 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
16 A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDQ0 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A024RDS1 (/IDA) A0A0A0MSM0 (/IDA)
(6 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 Q61699 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA) Q92598 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 Q92598 (/HDA) Q92598 (/HDA) Q92598 (/HDA) Q92598 (/HDA) Q92598 (/HDA)
Endocytic vesicle lumen GO:0071682
The volume enclosed by the membrane of an endocytic vesicle.
5 Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS) Q92598 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O95757 (/ISS) O95757 (/ISS) P48722 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O95757 (/ISS) O95757 (/ISS) P48722 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P48722 (/ISO) Q61699 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P48722 (/ISO) Q61699 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P48722 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q61699 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q61699 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...