The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Adhesion G-protein coupled receptor G1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
7 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
3 Q8K209 (/IDA) Q9Y653 (/IDA) Q9Y653 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q8K209 (/IMP)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q8K209 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 Q8K209 (/ISO)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
1 Q8K209 (/IDA)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cerebral cortex radial glia guided migration GO:0021801
The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Vascular endothelial growth factor production GO:0010573
The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
8 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K209 (/ISS) Q8K3V3 (/ISS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q9Y653 (/IMP) Q9Y653 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Vascular endothelial growth factor production GO:0010573
The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
2 Q9Y653 (/IDA) Q9Y653 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q8K209 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q8K209 (/ISO)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
1 Q8K209 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q8K209 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8K209 (/ISO)
Vascular endothelial growth factor production GO:0010573
The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 Q8K209 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q8K209 (/ISO)
Cerebral cortex regionalization GO:0021796
The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.
1 Q8K209 (/IMP)
Cerebral cortex radial glia guided migration GO:0021801
The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.
1 Q8K209 (/IMP)
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
1 Q8K209 (/IMP)
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
1 Q8K209 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q8K209 (/ISO)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
1 Q8K209 (/ISO)
Seminiferous tubule development GO:0072520
The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
1 Q8K209 (/IMP)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
1 Q8K209 (/IMP)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
1 Q8K209 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glial limiting end-foot GO:0097451
Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans.
9 Q50DM5 (/ISS) Q50DM6 (/ISS) Q50DM7 (/ISS) Q50DM7 (/ISS) Q50DM8 (/ISS) Q50DM8 (/ISS) Q8K3V3 (/ISS) Q9Y653 (/ISS) Q9Y653 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9Y653 (/TAS) Q9Y653 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9Y653 (/HDA) Q9Y653 (/HDA)
Glial limiting end-foot GO:0097451
Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans.
1 Q8K209 (/IDA)
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