The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 10: Transforming growth factor beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 32 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Type II transforming growth factor beta receptor binding GO:0005114
Interacting selectively and non-covalently with a type II transforming growth factor beta receptor.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Type I transforming growth factor beta receptor binding GO:0034713
Interacting selectively and non-covalently with a type I transforming growth factor beta receptor.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Type III transforming growth factor beta receptor binding GO:0034714
Interacting selectively and non-covalently with a type III transforming growth factor beta receptor.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P01137 (/IPI) P01137 (/IPI) P04202 (/IPI) P04202 (/IPI) P07200 (/IPI) P18341 (/IPI)
Transforming growth factor beta receptor binding GO:0005160
Interacting selectively and non-covalently with the transforming growth factor beta receptor.
3 P04202 (/TAS) P04202 (/TAS) P17246 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P01137 (/IPI) P01137 (/IPI) P07200 (/IPI)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
2 P01137 (/IPI) P01137 (/IPI)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
2 P04202 (/ISO) P04202 (/ISO)
Showing 1 to 10 of 32 entries

There are 450 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Mitotic cell cycle checkpoint GO:0007093
A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Showing 1 to 10 of 450 entries

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
63 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(53 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
62 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(52 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
58 E0A923 (/ISS) E0A923 (/ISS) E1BNK3 (/ISS) E1BNK3 (/ISS) E5LDB9 (/ISS) F1PI70 (/ISS) F1PI70 (/ISS) F6K637 (/ISS) F7HCV5 (/ISS) G1LYW1 (/ISS)
(48 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P01137 (/IDA) P01137 (/IDA) P04202 (/IDA) P04202 (/IDA) P17246 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
4 P01137 (/ISS) P01137 (/ISS) P07200 (/ISS) P18341 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P01137 (/TAS) P01137 (/TAS) P09533 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P01137 (/IDA) P01137 (/IDA) P17246 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P04202 (/ISO) P04202 (/ISO)
Showing 1 to 10 of 30 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...