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CATH Superfamily 2.60.120.920

SPRY domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: SPRY domain

The SPRY domain is named from SPla and the RYanodine Receptor. Its function is unknown. Distant homologues are domains in butyrophilin/marenostrin/pyrin PMID:9204703. Ca2+-release from the sarcoplasmic or endoplasmic reticulum, the intracellular Ca2+ store, is mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).

PMID:9204703 (INTERPRO:IPR003877)

GO Diversity

Unique GO annotations
639 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
1931 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 93
Domain clusters (>95% seq id): 24
Domain clusters (>35% seq id): 15
Unique PDBs: 48
Alignments
Structural Clusters (5A): 4
Structural Clusters (9A): 2
FunFam Clusters: 215
Function
Unique EC: 5
Unique GO: 639
Taxonomy
Unique Species: 1931
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