The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cupin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Putative lysine-specific demethylase 3BProbable JmjC domain-containing histone demethylation protein 2CBifunctional peptidase and arginyl-hydroxylase JMJD5tRNA wybutosine-synthesizing protein 5SC:2lysine-specific demethylase 2A isoform X1histone lysine demethylase PHF8 isoform X1PHD finger protein 2Lysine-specific demethylase 7ALysine-specific demethylase 7 homologSC:3Putative lysine-specific demethylase 5bputative lysine-specific demethylase JMJ16Transcriptional repressorLysine-specific demethylase 4ASC:4Cupin superfamily protein familyRibosomal oxygenase 1Ribosomal oxygenase 2SC:5lysine-specific demethylase 6A isoform X2Lysine-specific demethylase 4DJumonji, AT rich interactive domain 2Putative lysine-specific demethylase 6Bbifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X2PHD transcription factor (Rum1)Lysine-specific demethylase isoform Alysine-specific demethylase hairless isoform X1HSPB1-associated protein 1 homologLysine (K)-specific demethylase 5BbProbable lysine-specific demethylase ELF6Putative jumonji family transcription factorLysine-specific demethylase 8Transcription factor jumonji domain-containing proteinJumonji/arid domain-containing proteinLysine-specific demethylase lidlysine-specific demethylase JMJ30JmjC domain-containing protein 4lysine-specific demethylase 5C isoform X10Transcription factor jumonji (JmjC) domain-containing proteinTranscription factor jumonji (JmjC) domain-containing proteinPHD transcription factor Rum1Lysine-specific demethylase rbr-2Transcription factor jumonji (JmjC) domain-containing proteinJmjC domain-containing protein 8lysine-specific demethylase JMJ25 isoform X1lysine-specific demethylase 5C isoform X6Transcription factor jumonji (JmjC) domain-containing proteintRNA wybutosine-synthesizing protein 4Ubiquitously transcribed tetratricopeptide repeat protein Y-linked transcript variant 21F-box protein At1g78280JmjC domain-containing protein DPutative jumonji family transcription factorJmjC domain protein, putativePutative jumonji-like transcription factor family proteinJmjC domain containing proteinPredicted protein2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily proteinHistone H3-K36 demethylaseJhd2pJumonji domain containing 5Cupin-like domain-containing proteinLysine-specific demethylase JMJ25 isoform AEcm5pHistone demethylase JHD2Glucosamine 6-phosphate N-acetyltransferaseProbable inactive lysine-specific demethylase JMJ19JmjC domain containing proteinLysine-specific demethylase jmjd-3.1Uncharacterized proteinlysine-specific demethylase 8-likeUncharacterized protein, isoform AUTX (Ubiquitously transcribed TPR on X) homologLysine demethylase 5A40S ribosomal protein S4-3Lysine (K)-specific demethylase 4BLysine-specific demethylase 3Cupin_superfamily_protein/Cupin-like_domain_containing_protein_-_putativeJmjC domain containing proteinUncharacterized protein B13D15.230Lysine-specific demethylase 6A isoform 1Multicopy suppressor of chk1 protein 1Predicted proteinUncharacterized proteinJmjC domain-containing protein APredicted proteinUncharacterized proteinProtein CBG17151Uncharacterized proteinUncharacterized proteinCXXC finger protein 1Uncharacterized proteinPredicted proteinLysine-specific demethylase 4Mitochondrial carrier proteinChromosome 10, whole genome shotgun sequenceSpecific transcriptional repressorUncharacterized protein AT4g21430Protein associating with small stress protein PASS1RIOX2 isoform 6Uncharacterized proteinUnplaced genomic scaffold supercont2.18, whole genome shotgun sequenceJumonji domain-containing protein, putativeJumonji, AT-rich interactive domain 2aJuMonJi (Transcription factor) Domain proteinUncharacterized proteinHistone lysine demethylase PHF8JmjC domain containing proteinLysine-specific demethylase 4BJmjC domain-containing histone demethylase, putativeTranscription factor jumonji (JmjC) domain-containing proteinARID/BRIGHT DNA binding domain-containing proteinUncharacterized proteinLysine-specific demethylase rbr-2Predicted proteinJumonji/ARID domain-containing protein 2Uncharacterized proteinJmjC domain containing protein, expressedOs02g0109501 proteinPredicted proteinJmjd2b-prov proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinLysine-specific demethylase JMJ25GM16352Lysine-specific demethylase 8YALI0F28105pAGAP004022-PAC-module-binding factor APredicted proteinUncharacterized proteinlysine-specific demethylase 3BUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinAaceriAFL127CpYALI0C16390pProtein JumonjitRNA wybutosine-synthesizing protein 5Uncharacterized proteinYALI0B14443pUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinLid2 complex component jmj3Uncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinChromosome 7, whole genome shotgun sequencePredicted proteinUncharacterized proteinUncharacterized proteinOs02g0109400 proteinUncharacterized proteinLysine-specific demethylase REF6HR, lysine demethylase and nuclear receptor corepressorLysine demethylase 4CUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPHD zinc finger-containing proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinOs12g0169500 proteinPutative lysine-specific demethylase ELF6Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinPutative lysine-specific demethylase ELF6Uncharacterized proteinUncharacterized proteinLysine demethylase 4CUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPutative lysine-specific demethylase JMJ16Predicted proteinUncharacterized proteinUncharacterized proteinABR167CpUncharacterized proteinUncharacterized proteinPredicted proteinPutative lysine-specific demethylase JMJ16Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHSPB1 associated protein 1Predicted proteinUncharacterized proteinUncharacterized proteinMulticopy suppressor of chk1 protein 1Uncharacterized proteinBifunctional arginine demethylase and lysyl-hydroxylase psr-140S ribosomal protein S4-3Predicted proteinBifunctional lysine-specific demethylase and histidyl-hydroxylase NO66Predicted proteinUncharacterized proteinPredicted proteinUncharacterized proteinLid2 complex component lid2Uncharacterized proteinHistone lysine demethylase PHF8Predicted proteinPredicted proteinUncharacterized proteinUncharacterized protein40S ribosomal protein S4-3Uncharacterized proteinLysine (K)-specific demethylase 5AUncharacterized proteinUncharacterized proteinUncharacterized proteinBifunctional lysine-specific demethylase and histidyl-hydroxylase NO66Predicted protein
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FunFam 232: Lid2 complex component lid2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9HDV4 (/ISM)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9HDV4 (/IPI)
Histone demethylase activity (H3-trimethyl-K4 specific) GO:0034647
Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.
1 Q9HDV4 (/IDA)
Ubiquitin-like protein ligase activity GO:0061659
Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.
1 Q9HDV4 (/ISM)
Showing 1 to 4 of 4 entries

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
1 Q9HDV4 (/IMP)
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
1 Q9HDV4 (/IMP)
Heterochromatin assembly GO:0031507
The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.
1 Q9HDV4 (/IMP)
RITS complex localization GO:0034630
Any process in which a RITS complex is transported to, or maintained in, a specific location.
1 Q9HDV4 (/IMP)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
1 Q9HDV4 (/IMP)
Negative regulation of histone H3-K4 methylation GO:0051572
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
1 Q9HDV4 (/IMP)
Protein modification by small protein conjugation or removal GO:0070647
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
1 Q9HDV4 (/IC)
Showing 1 to 7 of 7 entries

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9HDV4 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9HDV4 (/IDA)
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 Q9HDV4 (/IDA)
Mating-type region heterochromatin GO:0031934
Heterochromatic regions of the chromosome found at silenced mating-type loci.
1 Q9HDV4 (/IDA)
Lid2 complex GO:0048189
A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p.
1 Q9HDV4 (/IDA)
Showing 1 to 5 of 5 entries
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