The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".
FunFam 1: FTO, alpha-ketoglutarate dependent dioxygenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS) |
|
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS) |
|
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q8BGW1 (/ISS) |
|
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) |
|
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) |
|
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) |
|
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | Q9C0B1 (/IDA) |
Showing 1 to 10 of 19 entries
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS) |
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q8BGW1 (/ISS) |
|
Oxidative single-stranded DNA demethylation GO:0035552
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) |
|
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
4 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) |
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Regulation of lipid storage GO:0010883
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
|
2 | Q8BGW1 (/IMP) Q9C0B1 (/IMP) |
|
Oxidative single-stranded DNA demethylation GO:0035552
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
|
2 | A0A2R8PY24 (/IMP) F1R5T4 (/IMP) |
Showing 1 to 10 of 33 entries
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q9C0B1 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
5 | Q2A121 (/ISS) Q2A121 (/ISS) Q5R7X0 (/ISS) Q68F54 (/ISS) Q8BGW1 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q8BGW1 (/IDA) Q9C0B1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8BGW1 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9C0B1 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9C0B1 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8BGW1 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q9C0B1 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q8BGW1 (/ISO) |
Showing 1 to 10 of 10 entries
