The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Jelly Rolls
".
FunFam 42: Hypoxia-inducible factor 1-alpha inhibitor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 33 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | Q8BLR9 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
8 | Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Oxygen sensor activity GO:0019826
Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
|
8 | Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) |
|
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-histidine dioxygenase activity GO:0036139
Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-asparagine 3-dioxygenase activity GO:0036140
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-asparagine 3-dioxygenase activity GO:0036140
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.
|
8 | Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
8 | Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) |
|
Ankyrin repeat binding GO:0071532
Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
|
8 | Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) Q9NWT6 (/IPI) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Peptidyl-histidine dioxygenase activity GO:0036139
Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Peptidyl-asparagine 3-dioxygenase activity GO:0036140
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
1 | Q8BLR9 (/ISO) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
1 | Q8BLR9 (/ISS) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q8BLR9 (/ISO) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q8BLR9 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q8BLR9 (/ISO) |
|
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
|
1 | Q8BLR9 (/ISO) |
|
Peptidyl-histidine dioxygenase activity GO:0036139
Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2.
|
1 | Q8BLR9 (/ISO) |
|
Peptidyl-asparagine 3-dioxygenase activity GO:0036140
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.
|
1 | Q8BLR9 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q8BLR9 (/ISO) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
1 | Q8BLR9 (/ISO) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q8BLR9 (/ISO) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q8BLR9 (/ISS) |
|
Ankyrin repeat binding GO:0071532
Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
|
1 | Q8BLR9 (/ISO) |
|
Ankyrin repeat binding GO:0071532
Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
|
1 | Q8BLR9 (/ISS) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peptidyl-histidine hydroxylation GO:0036138
The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-aspartic acid hydroxylation GO:0042264
The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-asparagine hydroxylation GO:0042265
The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Peptidyl-asparagine hydroxylation GO:0042265
The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine.
|
8 | Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) Q9NWT6 (/IMP) |
|
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
8 | Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) |
|
Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Positive regulation of vasculogenesis GO:2001214
Any process that activates or increases the frequency, rate or extent of vasculogenesis.
|
8 | Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) Q9NWT6 (/NAS) |
|
Peptidyl-histidine hydroxylation GO:0036138
The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Peptidyl-aspartic acid hydroxylation GO:0042264
The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Peptidyl-asparagine hydroxylation GO:0042265
The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
|
1 | P59723 (/IGI) |
|
Peptidyl-histidine hydroxylation GO:0036138
The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine.
|
1 | Q8BLR9 (/ISO) |
|
Peptidyl-aspartic acid hydroxylation GO:0042264
The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.
|
1 | Q8BLR9 (/ISO) |
|
Peptidyl-asparagine hydroxylation GO:0042265
The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine.
|
1 | Q8BLR9 (/ISO) |
|
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | Q8BLR9 (/ISO) |
|
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | Q8BLR9 (/ISS) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q8BLR9 (/ISO) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q8BLR9 (/ISS) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | Q8BLR9 (/ISO) |
|
Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
1 | Q8BLR9 (/ISO) |
|
Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
1 | Q8BLR9 (/ISS) |
|
Negative regulation of vasculature development GO:1901343
Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.
|
1 | P59723 (/IDA) |
|
Negative regulation of vasculature development GO:1901343
Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.
|
1 | P59723 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) Q9NWT6 (/TAS) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
8 | Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) Q9NWT6 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P59723 (/ISS) Q8BLR9 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8BLR9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8BLR9 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8BLR9 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q8BLR9 (/ISO) |
