The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Acid Proteases
".
FunFam 6: Cathepsin E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
8 | P14091 (/IDA) P14091 (/IDA) P16228 (/IDA) P70269 (/IDA) Q805F3 (/IDA) Q805F3 (/IDA) Q9D106 (/IDA) Q9GK11 (/IDA) |
|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
5 | P25796 (/ISS) P43159 (/ISS) Q800A0 (/ISS) Q805F2 (/ISS) Q805F2 (/ISS) |
|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
2 | P70269 (/ISO) Q9D7R7 (/ISO) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
2 | P14091 (/IDA) P14091 (/IDA) |
|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
1 | P20142 (/IMP) |
|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
1 | P20142 (/TAS) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | P70269 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P70269 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
7 | P25796 (/ISS) P43159 (/ISS) Q800A0 (/ISS) Q805F2 (/ISS) Q805F2 (/ISS) Q805F3 (/ISS) Q805F3 (/ISS) |
|
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
4 | P14091 (/IDA) P14091 (/IDA) P16228 (/IDA) P70269 (/IDA) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
4 | P0DJD7 (/TAS) P0DJD7 (/TAS) P0DJD8 (/TAS) P0DJD9 (/TAS) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
2 | P14091 (/IDA) P14091 (/IDA) |
|
Positive regulation of antibacterial peptide production GO:0002803
Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.
|
1 | P20142 (/IMP) |
|
Positive regulation of antibacterial peptide production GO:0002803
Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.
|
1 | Q9D7R7 (/ISO) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
1 | P70269 (/ISO) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
1 | P20142 (/TAS) |
|
Digestion GO:0007586
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
|
1 | P20142 (/TAS) |
|
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
|
1 | P16228 (/IMP) |
|
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
|
1 | P70269 (/ISO) |
|
Protein metabolic process GO:0019538
The chemical reactions and pathways involving a protein. Includes protein modification.
|
1 | Q9D106 (/TAS) |
|
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
1 | P70269 (/ISO) |
|
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
1 | Q9GK11 (/IDA) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
7 | P25796 (/ISS) P43159 (/ISS) Q800A0 (/ISS) Q805F2 (/ISS) Q805F2 (/ISS) Q805F3 (/ISS) Q805F3 (/ISS) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
4 | P14091 (/IDA) P14091 (/IDA) P16228 (/IDA) P70269 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
4 | P0DJD7 (/HDA) P0DJD7 (/HDA) P0DJD8 (/HDA) P0DJD9 (/HDA) |
|
Multivesicular body lumen GO:0097486
The volume enclosed by the outermost membrane of a multivesicular body.
|
4 | P0DJD7 (/TAS) P0DJD7 (/TAS) P0DJD8 (/TAS) P0DJD9 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P20142 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9D7R7 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P20142 (/TAS) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
1 | P70269 (/ISO) |
