The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35: Plasmepsin-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
19 Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS) Q8IM15 (/ISS)
(9 more)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
16 Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS)
(6 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hemoglobin catabolic process GO:0042540
The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids.
16 Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS)
(6 more)
Hemoglobin catabolic process GO:0042540
The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids.
7 Q8IM16 (/ISS) Q8IM16 (/ISS) Q8IM16 (/ISS) Q8IM16 (/ISS) Q8IM16 (/ISS) Q8IM16 (/ISS) Q8IM16 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Food vacuole GO:0020020
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
24 Q8I6V3 (/IDA) Q8I6V3 (/IDA) Q8I6V3 (/IDA) Q8I6V3 (/IDA) Q8I6V3 (/IDA) Q8IM15 (/IDA) Q8IM15 (/IDA) Q8IM15 (/IDA) Q8IM15 (/IDA) Q8IM15 (/IDA)
(14 more)
Food vacuole GO:0020020
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
11 Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS) Q7KQM4 (/TAS)
(1 more)
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