The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Acid Proteases
".
FunFam 23: Aspartic protease
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
32 |
G8B6X1 (/IDA)
G8B6X1 (/IDA)
G8B6Y8 (/IDA)
P0CY27 (/IDA)
P0CY29 (/IDA)
P0CY29 (/IDA)
P0DJ06 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
(22 more) |
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
5 | P40583 (/ISS) Q12303 (/ISS) Q12303 (/ISS) Q12303 (/ISS) Q12303 (/ISS) |
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
|
3 | P43094 (/IMP) Q5AC08 (/IMP) Q5AC08 (/IMP) |
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
1 | P0DJ06 (/IDA) |
Showing 1 to 4 of 4 entries
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
14 |
G8B6X1 (/IDA)
G8B6X1 (/IDA)
G8B6Y8 (/IDA)
P0CY27 (/IDA)
P0CY29 (/IDA)
P0CY29 (/IDA)
P0DJ06 (/IDA)
P43094 (/IDA)
Q59SU1 (/IDA)
Q5A8N2 (/IDA)
(4 more) |
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
|
14 |
P32329 (/IGI)
P32329 (/IGI)
P32329 (/IGI)
P32329 (/IGI)
P32329 (/IGI)
P32329 (/IGI)
P32329 (/IGI)
P40583 (/IGI)
P53379 (/IGI)
Q12303 (/IGI)
(4 more) |
Signal transduction involved in filamentous growth GO:0001402
Relaying of environmental signals promoting filamentous growth.
|
8 | P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P53379 (/IMP) |
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
7 | P0CY27 (/IMP) P0CY29 (/IMP) P0CY29 (/IMP) P0DJ06 (/IMP) P43094 (/IMP) Q5AC08 (/IMP) Q5AC08 (/IMP) |
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
|
7 | P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) |
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
|
7 | P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) P32329 (/IMP) |
Peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion GO:0071432
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.
|
7 | P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) P32329 (/IGI) |
Adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion GO:0000754
In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
|
6 | P12630 (/IDA) P12630 (/IDA) P12630 (/IDA) P12630 (/IDA) P12630 (/IDA) P12630 (/IDA) |
Adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion GO:0000754
In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
|
6 | P12630 (/IMP) P12630 (/IMP) P12630 (/IMP) P12630 (/IMP) P12630 (/IMP) P12630 (/IMP) |
Signal peptide processing GO:0006465
The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.
|
6 | P0CY27 (/IDA) P0CY29 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) Q5AC08 (/IDA) Q5AC08 (/IDA) |
Showing 1 to 10 of 28 entries
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
19 |
G8B6X1 (/IDA)
G8B6X1 (/IDA)
G8B6Y8 (/IDA)
P0CY27 (/IDA)
P0CY29 (/IDA)
P0CY29 (/IDA)
P0DJ06 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
(9 more) |
Anchored component of plasma membrane GO:0046658
The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
12 |
P32329 (/IDA)
P32329 (/IDA)
P32329 (/IDA)
P32329 (/IDA)
P32329 (/IDA)
P32329 (/IDA)
P32329 (/IDA)
Q12303 (/IDA)
Q12303 (/IDA)
Q12303 (/IDA)
(2 more) |
Fungal-type cell wall GO:0009277
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
|
11 |
G8B6X1 (/IDA)
G8B6X1 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P12630 (/IDA)
P40583 (/IDA)
P53379 (/IDA)
(1 more) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
6 | P12630 (/HDA) P12630 (/HDA) P12630 (/HDA) P12630 (/HDA) P12630 (/HDA) P12630 (/HDA) |
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
|
3 | P43094 (/IDA) Q5AC08 (/IDA) Q5AC08 (/IDA) |
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
1 | P53379 (/HDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q59SU1 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q59SU1 (/IMP) |
Anchored component of membrane GO:0031225
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
1 | Q59SU1 (/IDA) |
Showing 1 to 9 of 9 entries